Evidence map›Paper›PMID 31080832›Full record

ReviewBioMed research international2019

Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases.

Cinzia Forni, Francesco Facchiano, Manuela Bartoli, Stefano Pieretti, Antonio Facchiano, Daniela D'Arcangelo, Sandro Norelli, Giorgia Valle, Roberto Nisini, Simone Beninati and 2 more

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed
23.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 508 citations in OpenAlex.

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  12. Evaluation of Nutraceutical Potential ofFood science & nutrition · 2025
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  17. TheFrontiers in nutrition · 2025
    Article
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102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Cinzia ForniDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Francesco FacchianoDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0003-4313-0617
Manuela BartoliDepartment of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Stefano PierettiNational Center for Drug Research and Evaluation, Istituto Superiore di Sanità, Rome, Italy.
Antonio FacchianoLaboratory of Molecular Oncology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.ORCID 0000-0002-4243-2392
Daniela D'ArcangeloLaboratory of Molecular Oncology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.ORCID 0000-0002-7862-3289
Sandro NorelliDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Giorgia ValleDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Roberto NisiniDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0003-1077-423X
Simone BeninatiDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.ORCID 0000-0002-2704-0745
Claudio TabolacciDepartment of Medicine, University Campus Bio-Medico, Rome, Italy.ORCID 0000-0001-5001-285X
Ravirajsinh N JadejaDepartment of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University, Augusta, GA, USA.ORCID 0000-0002-1712-454X
Istituto Superiore di Sanità · ITUniversity of Rome Tor Vergata · ITAugusta University · USIstituto Dermopatico dell'Immacolata · ITUniversità Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, leading to important cellular dysfunctions. The imbalance between ROS production and antioxidant defenses brings to oxidative stress conditions and, related to accumulation of ROS, aging-associated diseases. The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs.

Indexed as

AgingAnimalsAntioxidantsHumansMetabolic SyndromeNeurodegenerative DiseasesOxidative StressPhytochemicalsReactive Oxygen SpeciesAntioxidantsPhytochemicalsReactive Oxygen Species

Identifiers

PMID31080832
PMCPMC6475554
OpenAlexW2933553758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.