ArticleBioMed research international2019
High Glucose Enhances the Odonto/Osteogenic Differentiation of Stem Cells from Apical Papilla via NF-KappaB Signaling Pathway.
Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Association between diabetes and pulp stone prevalence and morphological characteristics: a CBCT-based retrospective study.BMC oral health · 2026Observational
- The investigation of effects, signal pathways, and applications of high glucose on dental pulp stem cells.Journal of dental sciences · 2025Article
- 3D X-ray microscope acts as an accurate and effective equipment of pathological diagnosis in craniofacial imaging.Scientific reports · 2024Article
- Article
- Effects of Different Basal Cell Culture Media upon the Osteogenic Response of hMSCs Evaluated byInternational journal of molecular sciences · 2022Article
- High glucose mediates apoptosis and osteogenesis of MSCs via downregulation of AKT-Sirt1-TWIST.Molecular biology reports · 2022Article
- P75 neurotrophin receptor positively regulates the odontogenic/osteogenic differentiation of ectomesenchymal stem cells via nuclear factor kappa-B signaling pathway.Bioengineered · 2022Article
- Multidifferentiation potential of dental-derived stem cells.World journal of stem cells · 2021Review
- Overactivation of the NF-κB pathway impairs molar enamel formation.Oral diseases · 2020Article
- Molecular Insight into Odontogenesis in Hyperglycemic Environment: A Systematic Review.Journal of pharmacy & bioallied sciences · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe transport and metabolism of glucose are important during mammalian development. High glucose can mediate the biological characteristics of mesenchymal stem cells (MSCs). However, the role of high glucose in the odonto/osteogenic differentiation of stem cells from apical papilla (SCAPs) is unclear. MATERIALS AND
methodsSCAPs were isolated and identified
resultsSCAPs in 25mmol/L glucose group expressed the maximum proteins of RUNX2 and ALP as compared with those in 5, 10, and 15 mmol/L groups. MTT assay showed that 25 mmol/L glucose suppressed the proliferation of SCAPs. ALP assay, alizarin red staining, real-time RT-PCR, and western blot showed 25 mmol/L high glucose can obviously enhance the odonto/osteogenic capacity of SCAPs. Moreover, the NF-
conclusionsHigh glucose can enhance the odonto/osteogenic capacity of SCAPs via NF-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.