Evidence map›Paper›PMID 31080810›Full record

ReviewBioMed research international2019

Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases.

Qian Jiang, Jiashun Chen, Chengbo Yang, Yulong Yin, Kang Yao

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 1 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 1 synthesis or guideline pooled it, 318 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026
    Review
  8. Article
  9. Phages and quorum sensing: findings to consider in phage therapy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Disclosing New Insights on Pyrazolo[3,4-Journal of microbiology and biotechnology · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Beyond Antibiotics: What the Future Holds.Antibiotics (Basel, Switzerland) · 2024
    Review
  20. HPLC-PDA Analysis of Polyacetylene Glucosides fromPharmaceuticals (Basel, Switzerland) · 2024
    Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Qian JiangLaboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, China.ORCID 0000-0002-7840-0210
Jiashun ChenLaboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, China.
Chengbo YangDepartment of Animal Science, University of Manitoba, Winnipeg, MB, Canada R3T 2N2.
Yulong YinLaboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, China.ORCID 0000-0001-6112-6975
Kang YaoLaboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, China.ORCID 0000-0001-5251-4116
Chinese Academy of Sciences · CNUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial quorum sensing (QS) is a cell-to-cell communication in which specific signals are activated to coordinate pathogenic behaviors and help bacteria acclimatize to the disadvantages. The QS signals in the bacteria mainly consist of acyl-homoserine lactone, autoinducing peptide, and autoinducer-2. QS signaling activation and biofilm formation lead to the antimicrobial resistance of the pathogens, thus increasing the therapy difficulty of bacterial diseases. Anti-QS agents can abolish the QS signaling and prevent the biofilm formation, therefore reducing bacterial virulence without causing drug-resistant to the pathogens, suggesting that anti-QS agents are potential alternatives for antibiotics. This review focuses on the anti-QS agents and their mediated signals in the pathogens and conveys the potential of QS targeted therapy for bacterial diseases.

Indexed as

Acyl-ButyrolactonesAnimalsAnti-Bacterial AgentsBacteriaBacterial InfectionsBacterial ProteinsBiofilmsHomoserineHumansLactonesProspective StudiesQuorum SensingSignal TransductionVirulence FactorsAcyl-ButyrolactonesAnti-Bacterial AgentsBacterial ProteinsHomoserineLactonesN-octanoylhomoserine lactoneVirulence Factors

Identifiers

PMID31080810
PMCPMC6475571
OpenAlexW2932582301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.