Evidence map›Paper›PMID 31080747›Full record

ArticleToxicology reports2019

Contrast-induced nephropathy in an animal model: Evaluation of novel biomarkers in blood and tissue samples.

Charalampos Mamoulakis, Irene Fragkiadoulaki, Phaedra Karkala, Georgios Georgiadis, Ioannis-Erineos Zisis, Polychronis Stivaktakis, Alexandra Kalogeraki, Ioannis Tsiaoussis, Tatyana Burykina, George Lazopoulos and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  6. Article
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  12. Review
  13. 5-HMF induces anaphylactoid reactionsToxicology reports · 2020
    Article
  14. Renoprotective effects of stevia (Toxicology reports · 2019
    Article
  15. Contrast-Induced Acute Kidney Injury: Review and Practical Update.Clinical Medicine Insights. Cardiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Charalampos MamoulakisDepartment of Urology, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Crete, Greece.
Irene FragkiadoulakiDepartment of Urology, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Crete, Greece.
Phaedra KarkalaDepartment of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, 71003, Greece.
Georgios GeorgiadisDepartment of Urology, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Crete, Greece.
Ioannis-Erineos ZisisDepartment of Urology, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Crete, Greece.
Polychronis StivaktakisDepartment of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, 71003, Greece.
Alexandra KalogerakiDepartment of Pathology-Cytopathology, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Crete, Greece.
Ioannis TsiaoussisLaboratory of Anatomy-Histology-Embryology, University of Crete, Medical School, Heraklion, Crete, Greece.
Tatyana BurykinaDepartment of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st., 119991, Moscow, Russia.
George LazopoulosDepartment of Cardiothoracic Surgery, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Crete, Greece.
Konstantinos TsarouhasDepartment of Cardiology, University General Hospital of Larisa, Larissa, Greece.
Dimitrios KouretasDepartment of Biochemistry and Biotechnology, University of Thessaly, 41500, Larissa, Greece.
Aristides TsatsakisDepartment of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion, 71003, Greece.
University of Crete · GRUniversity Hospital of Heraklion · GRSechenov University · RUUniversity of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identification of novel biomarkers of contrast-induced nephropathy (CIN) that may more accurately detect renal function changes; reflect kidney damage; assist monitoring; and elucidate pathophysiology attract considerable scientific attention nowadays. To evaluate novel biomarkers of nephrotoxicity in blood/tissue samples of a CIN model, 10 New Zealand white rabbits were divided into group 1 (n = 5; iopromide) and group 2 (n = 5; control). Blood was drawn at 0 h (immediately), 24 h and 48 h after contrast medium (CM) administration. Animals were euthanized at 48 h and kidneys were removed. Serum creatinine (sCr)/symmetric-asymmetric dimethylarginine (SDMA-ADMA) levels were measured. CM genotoxic/cytotoxic effect was investigated 48 h post-CM exposure using micronucleus assay in lymphocytes. Cytological examination was conducted using touch preparation technique (TPT). All animals in group 1 developed CIN: mean sCr levels increased by 68.2% within 48 h. Significant SDMA-ADMA level elevation was observed at 0 h and 24 h with insignificant drop at 48 h in group 1, remaining normal in group 2 at all time-points. Significant increase in bi-nucleated cells with micronuclei and micronuclei frequency was detected in group 1. Cytokinesis block proliferation index was reduced insignificantly in group 1. TPT revealed degenerative lesions/inflammation, cell degeneration, abnormal uterine tubular casts and rubella in kidneys of all animals in group 1. Group 2 presented normal cells.

Indexed as

ADMA, asymmetric dimethylarginineAKI, acute kidney injuryAnimalANOVA, analysis of varianceARRIVE, animal research: reporting of in vivo experimentsAsymmetric dimethylarginineAVMA, American Veterinary Medical AssociationBNMN, Bi-nucleated cells with micronucleiCBPI, cytokinesis block proliferation indexCIN, contrast-induced nephropathyCKD, chronic kidney diseaseCM, contrast mediumContrast mediaESI, electrospray ionizationGFR, glomerular filtration rateIopromideKidneyKIM-1, kidney injury molecule-1LC–MS, liquid chromatography mass spectrometryMN, micronucleiModelsNephropathyNephrotoxicityNGAL, meutrophil gelatinase–associated lipocalinNO, nitric oxideOECD, Organisation for Economic Co-operation and DevelopmentRBF, renal blood flowROS, reactive oxygen speciesSCR, serum creatinineSDMA, symmetric dimethylarginineSD, standard deviationSymmetric dimethylarginineTPT, touch preparation technique

Identifiers

PMID31080747
PMCPMC6506864
OpenAlexW2943616399

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.