ArticleJournal of pregnancy2019
Changes in Gastric Smooth Muscle Cell Contraction during Pregnancy: Effect of Estrogen.
Article in Journal of pregnancy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Potential Biological Mechanisms Underlying Susceptibility to Nausea and Vomiting of Pregnancy in Women with Polycystic Ovary Syndrome: A Narrative Review.International journal of women's health · 2026Review
- Sex hormones and functional gastrointestinal disorders in menopausal women.Frontiers in endocrinology · 2026Review
- Anesthetic Management of the Pregnant Patient Undergoing Non-Obstetric Surgery.Medicina (Kaunas, Lithuania) · 2025Review
- The effect of combined fig-Walnut syrup on functional constipation in pregnant women: a randomized controlled trial.Nutrition & metabolism · 2025Article
- Pregnancy affects maternal performance, feed intake, and digestion kinetics parameters in beef heifers.Journal of animal science · 2025Article
- Risk factors for constipation during pregnancy: a multicentre prospective cohort study.BMC pregnancy and childbirth · 2024Observational
- Synthesis, Regulatory Factors, and Signaling Pathways of Estrogen in the Ovary.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Progesterone inhibitory role on gastrointestinal motility.Physiological research · 2022Review
- Calcium and potassium channels are involved in curcumin relaxant effect on tracheal smooth muscles.Pharmaceutical biology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that pregnancy is associated with frequent gastrointestinal (GI) disorders and symptoms. Moreover, previous reports have shown that estrogen, which changes in levels during pregnancy, participates in the regulation of GI motility and is involved in the pathogenesis of various functional disorders in the stomach. The aim of the current study was to explore the changes in the expression of estrogen receptors (ERs) and examine the effect of estrogen on nitric oxide- (NO-) cyclic guanosine monophosphate (cGMP) pathway and thus relaxation in gastric smooth muscle cells (GSMC) during pregnancy. Single GSMC from early-pregnant and late-pregnant Sprague-Dawley rats were used. Protein and mRNA expression levels of ERs were measured via specifically designed enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR), respectively. NO and cGMP levels were measured via specifically designed ELISA kits. Effect of estrogen on acetylcholine- (ACh-) induced contraction of single GSMC was measured via scanning micrometry in the presence or absence of the NO synthase inhibitor,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.