ArticleJournal of intensive care2019
Quantitative capillary refill time predicts sepsis in patients with suspected infection in the emergency department: an observational study.
Article in Journal of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Microcirculation Monitoring in Septic Shock: Focused Review.Medicina (Kaunas, Lithuania) · 2026Review
- A Screening Tool to Predict Sepsis in Patients With Suspected Infection in the Emergency Department.Cureus · 2025Article
- Research Progress on the Measurement Methods and Clinical Significance of Capillary Refill Time.Sensors (Basel, Switzerland) · 2024Review
- Can plethysmographic capillary refill time predict lactate during sepsis? An observational study from Morocco.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2024Article
- Pilot study on optimizing pressure for standardized capillary refill time measurement.Heliyon · 2024Article
- Capillary Refill Time and Serum Lactate as Predictors of Mortality and Postoperative Extracorporeal Membrane Oxygenation Requirement in Congenital Heart Surgery.Children (Basel, Switzerland) · 2023Article
- Point-Of-Care Capillary Refill Technology Improves Accuracy of Peripheral Perfusion Assessment.Frontiers in medicine · 2021Article
- Pulse oximetry-based capillary refilling evaluation predicts postoperative outcomes in liver transplantation: a prospective observational cohort study.BMC anesthesiology · 2020Observational
- Cutting-Edge Technology for Rapid Bedside Assessment of Capillary Refill Time for Early Diagnosis and Resuscitation of Sepsis.Frontiers in medicine · 2020Article
- Advances in the Approaches Using Peripheral Perfusion for Monitoring Hemodynamic Status.Frontiers in medicine · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOutcomes in emergent patients with suspected infection depend on how quickly clinicians evaluate the patients and start treatment. This study was performed to compare the predictive ability of the quantitative capillary refill time (Q-CRT) as a new rapid index versus the quick sequential organ failure assessment (qSOFA) score and the systemic inflammatory response syndrome (SIRS) score for sepsis screening in the emergency department.
methodsThis was a multicenter, observational, retrospective study of adult patients with suspected infection. The area under the curve (AUC) of receiver operating characteristic curve analyses and multivariate analyses were used to explore associations of the Q-CRT with the qSOFA score, SIRS score, and lactate concentration.
resultsOf the 75 enrolled patients, 48 had sepsis. The AUC, sensitivity, and specificity of Q-CRT were 0.74, 58%, and 81%, respectively; those for the qSOFA score were 0.83, 66%, and 100%, respectively; those for the SIRS score were 0.61, 81%, and 40%, respectively, for SIRS score; and those for the lactate concentration were 0.76, 72%, and 81%, respectively. We found no statistically significant differences in the AUC between the scores. We then combined the Q-CRT and qSOFA score (Q-CRT/qSOFA combination) for sepsis screening. The AUC, sensitivity, and specificity of Q-CRT/qSOFA combination were 0.82, 83%, and 81%, respectively.
conclusionsIn this study, Q-CRT/qSOFA combination had better sensitivity than the qSOFA score alone and better specificity than the SIRS score alone. There was no significant difference in accuracy between Q-CRT/qSOFA combination and the qSOFA score or lactate concentration. The ability of the Q-CRT to predict sepsis may be similar to that of the qSOFA score or serum lactate concentration; therefore, measurement of the Q-CRT may be an alternative for invasive measurement of the blood lactate concentration in evaluating patients with suspected sepsis.
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