Evidence map›Paper›PMID 31080603›Full record

ArticleUnited European gastroenterology journal2019

Rate of missed oesophageal cancer at routine endoscopy and survival outcomes: A multicentric cohort study.

Enrique Rodríguez de Santiago, Nerea Hernanz, Héctor Miguel Marcos-Prieto, Miguel Ángel De-Jorge-Turrión, Eva Barreiro-Alonso, Carlos Rodríguez-Escaja, Andrea Jiménez-Jurado, María Sierra-Morales, Isabel Pérez-Valle, Nadja Machado-Volpato and 7 more

Abstract readMulticenter Study
In one paragraph

Article in United European gastroenterology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Artificial Intelligence for Esophageal Precancerous Lesions and Esophageal Cancer.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Artificial Intelligence in Upper Gastrointestinal Diagnosis.The Korean journal of helicobacter and upper gastrointestinal research · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Enrique Rodríguez de SantiagoDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, University of Alcala, Madrid, Spain.
Nerea HernanzDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, University of Alcala, Madrid, Spain.
Héctor Miguel Marcos-PrietoGastroenterology Department, Hospital Universitario de Salamanca, University of Salamanca, IBSAL (Instituto de Investigación Biomédica de Salamanca), Salamanca, Spain.
Miguel Ángel De-Jorge-TurriónDepartment of Gastroenterology and Hepatology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Eva Barreiro-AlonsoGastroenterology Unit, Hospital Universitario de Cabueñes, Gijón, Spain.
Carlos Rodríguez-EscajaDepartment of Gastroenterology and Hepatology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Andrea Jiménez-JuradoGastroenterology Department, Hospital Universitario de Salamanca, University of Salamanca, IBSAL (Instituto de Investigación Biomédica de Salamanca), Salamanca, Spain.
María Sierra-MoralesDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, University of Alcala, Madrid, Spain.
Isabel Pérez-ValleGastroenterology Unit, Hospital Universitario de Cabueñes, Gijón, Spain.
Nadja Machado-VolpatoDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, University of Alcala, Madrid, Spain.
María García-PradaGastroenterology Department, Hospital Universitario de Salamanca, University of Salamanca, IBSAL (Instituto de Investigación Biomédica de Salamanca), Salamanca, Spain.
Laura Núñez-GómezDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, University of Alcala, Madrid, Spain.
Andrés Castaño-GarcíaGastroenterology Department, Hospital Universitario de Salamanca, University of Salamanca, IBSAL (Instituto de Investigación Biomédica de Salamanca), Salamanca, Spain.
Ana García García de ParedesDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, University of Alcala, Madrid, Spain.
Beatriz PeñasDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, University of Alcala, Madrid, Spain.
Enrique Vázquez-SequeirosDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, University of Alcala, Madrid, Spain.
Agustín AlbillosDepartment of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, University of Alcala, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Missed oesophageal cancer (MEC) at upper gastrointestinal endoscopy (UGE) is poorly documented. Objective: The objectives of this study were: (1) to assess the rate, predictors and survival of MEC; (2) to compare MEC and non-MEC tumours. Methods: This was a retrospective cohort study conducted at four tertiary centres. Oesophageal cancers (ECs) diagnosed between 2008 and 2015 were included. Patients with a premalignant condition (Barrett, achalasia), prior diagnosis of EC or oesophagogastric junction tumour of gastric origin were excluded. MEC was defined as EC detected within 36 months after negative UGE. Results: 123,395 UGEs were performed during the study period, with 502 ECs being diagnosed (0.4%). A total of 391 ECs were finally included. Overall MEC rate was 6.4% (95% confidence intervals (CI): 4.4-9.3%). The interval between negative and diagnostic UGE was less than 2 years in 84% of the cases. Multivariate analysis showed that a negative endoscopy was associated with proton pump inhibitor (PPI) therapy and less experienced endoscopists. MEC was smaller than non-MEC at diagnosis (25 versus 40 mm, Conclusions: MEC accounted for 6.4% of all ECs and was associated with poor survival. High-quality UGE and awareness of MEC may help to reduce its incidence.

Indexed as

Endoscopy, Digestive SystemAgedAged, 80 and overCohort StudiesEsophageal NeoplasmsFemaleHumansMaleMiddle AgedMissed DiagnosisRetrospective StudiesSurvival AnalysisMissed canceroesophageal neoplasmsoesophagitisoesophagogastroduodenoscopysurvival

Identifiers

PMID31080603
PMCPMC6498796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.