Evidence map›Paper›PMID 31080589›Full record

ArticleJournal of nutritional science2019

Addition of milk fat globule membrane-enriched supplement to a high-fat meal attenuates insulin secretion and induction of soluble epoxide hydrolase gene expression in the postprandial state in overweight and obese subjects.

Elizabeth Beals, S G Kamita, R Sacchi, E Demmer, N Rivera, T S Rogers-Soeder, E R Gertz, M D Van Loan, J B German, B D Hammock and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nutritional science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01811329 (Effects of Dairy Fat on Postprandial Inflammation- Phase 1), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01811329 naactive not recruitingnot on this map

Effects of Dairy Fat on Postprandial Inflammation- Phase 1

TypeinterventionalSponsorUniversity of California, DavisRan2013 to 2027Enrolled38ConditionsMetabolic Syndrome, ObesityArmsDairy fat, Dairy fat + MFGM, Palm fat, Palm fat + MFGM
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Elizabeth BealsDepartment of Nutrition, University of California, Davis, CA, USA.ORCID 0000-0002-3223-9345
S G KamitaDepartment of Entomology, University of California, Davis, CA, USA.
R SacchiDepartment of Nutrition, University of California, Davis, CA, USA.
E DemmerDepartment of Nutrition, University of California, Davis, CA, USA.
N RiveraDepartment of Nutrition, University of California, Davis, CA, USA.
T S Rogers-SoederDepartment of Nutrition, University of California, Davis, CA, USA.
E R GertzUS Department of Agriculture/Agricultural Research Service Western Human Nutrition Research Center, Davis, CA, USA.
M D Van LoanDepartment of Nutrition, University of California, Davis, CA, USA.
J B GermanFoods for Health Institute, University of California, Davis, CA, USA.
B D HammockDepartment of Entomology, University of California, Davis, CA, USA.
J T SmilowitzFoods for Health Institute, University of California, Davis, CA, USA.
A M ZivkovicDepartment of Nutrition, University of California, Davis, CA, USA.
University of California, Davis · USAgricultural Research Service · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CVD and associated metabolic diseases are linked to chronic inflammation, which can be modified by diet. The objective of the present study was to determine whether there is a difference in inflammatory markers, blood metabolic and lipid panels and lymphocyte gene expression in response to a high-fat dairy food challenge with or without milk fat globule membrane (MFGM). Participants consumed a dairy product-based meal containing whipping cream (WC) high in saturated fat with or without the addition of MFGM, following a 12 h fasting blood draw. Inflammatory markers including IL-6 and C-reactive protein, lipid and metabolic panels and lymphocyte gene expression fold changes were measured using multiplex assays, clinical laboratory services and TaqMan real-time RT-PCR, respectively. Fold changes in gene expression were determined using the Pfaffl method. Response variables were converted into incremental AUC, tested for differences, and corrected for multiple comparisons. The postprandial insulin response was significantly lower following the meal containing MFGM (

Indexed as

Dietary SupplementsMealsAdolescentAdultAgedBiomarkersCholesterolC-Reactive ProteinCytokinesDairy ProductsDietEpoxide HydrolasesFastingFatty AcidsFemaleGene ExpressionBiomarkersCholesterolC-Reactive ProteinCytokinesEPHX2 protein, humanEpoxide HydrolasesFatty AcidsGlycolipidsGlycoproteinsInsulinInterleukin-6milk fat globuleARA, arachidonic acidCD14, cluster of differentiation 14Chol:HDL, cholesterol:HDL-cholesterol ratioCRP, C-reactive proteinCytokinesEPHX2, soluble epoxide hydrolaseiAUC, incremental AUCInflammatory markersLBP, lipopolysaccharide binding proteinLPS, lipopolysaccharideLTBR, lymphotoxin β receptorMetabolic syndromeMetS, metabolic syndromeMFGM, milk fat globule membraneMilk fat globule membraneOverweightPostprandial inflammationSAA, serum amyloid ASaturated fatsEH, soluble epoxide hydrolaseT2DM, type 2 diabetes mellitusWC, whipping cream

Identifiers

PMID31080589
PMCPMC6498758
OpenAlexW2941893860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.