Evidence map›Paper›PMID 31080473›Full record

ArticleJournal of geriatric cardiology : JGC2019

The association of atrial fibrillation and dementia incidence: a meta-analysis of prospective cohort studies.

Dao-Shen Liu, Jing Chen, Wei-Ming Jian, Guang-Rong Zhang, Zhi-Rong Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of geriatric cardiology : JGC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Beyond the beats: a systematic review of the underlying inflammatory pathways between atrial fibrillation and cognitive decline.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Guideline
  3. Umbrella review and Delphi study on modifiable factors for dementia risk reduction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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  19. Atrial fibrillation: villain or bystander in vascular brain injury.European heart journal supplements : journal of the European Society of Cardiology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dao-Shen LiuDepartment of Neurology, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China.
Jing ChenDepartment of Neurology, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China.
Wei-Ming JianDepartment of Geriatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China.
Guang-Rong ZhangDepartment of Neurology, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China.
Zhi-Rong LiuDepartment of Neurology, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China.
Xijing Hospital · CNAir Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess and synthesize the prospective cohort studies published so far on the association between atrial fibrillation (AF) and dementia incidence.

methodsWe searched PubMed, Web of Science, and the Cochrane Library for potential studies published in English previous to April 2018. Two independent reviewers screened the search results for prospective cohort studies reporting the association between AF and dementia incidence in patients with normal cognitive function at baseline and not suffering from an acute stroke. The Newcastle-Ottawa Scale was adopted to evaluate the quality of the included studies. The pooled hazard ratio (HR) of AF for dementia was calculated with the Comprehensive Meta-Analysis software, version 2. Heterogeneity and publication bias were assessed with the

resultsWe finally identified 11 prospective cohort studies covering 112,876 patients. All the included studies reported an adjusted HR obtained in multiple Cox regression models. The qualities of the included studies ranged from moderate to high. In pooled analysis with a fixed-effects model, AF was independently associated with dementia incidence (HR = 1.34, 95% CI: 1.24-1.44). Subgroup analysis of studies considering anticoagulation as an important confounding factor achieved a similar result. Based on the

conclusionsThe results of our meta-analysis further confirmed that AF was an independent risk factor for dementia in patients with normal baseline cognitive function not suffering from acute stroke. Screening for dementia in AF patients and including dementia as an independent outcome in large AF treatment trials is warranted.

Indexed as

ArrhythmiasAtrial fibrillationCognitive impairmentDementiaMeta-analysis

Identifiers

PMID31080473
PMCPMC6500564
OpenAlexW2940372276

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.