ArticleFrontiers in immunology2019
IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Immunomodulatory effect of borax on murine hepatocellular carcinoma induced by diethylnitrosamine.Scientific reports · 2026Article
- Leveraging a synthetic biology approach to enhance BCG-mediated expansion of Vγ9Vδ2 T cells.PloS one · 2026Article
- Vγ9Vδ2 T cells in tuberculosis: protective immunity and translational perspectives.Frontiers in immunology · 2026Review
- Expansion strategies for Vδ2 γδT cells in cancer immunotherapy: Activation, cytokines, and culture conditions.World journal of clinical oncology · 2025Review
- Oncolytic cytomegaloviruses expressing EGFR-retargeted fusogenic glycoprotein complex and drug-controllable interleukin 12.Cell reports. Medicine · 2025Article
- Vγ9Vδ2 T cells expanded with vitamin C combined with HMBPPFrontiers in cellular and infection microbiology · 2025Article
- Analysis of the components of Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) and its regulation of γδ T-cell function.Cellular & molecular biology letters · 2024Article
- γδ T cell-mediated activation of cDC1 orchestrates CD4Frontiers in immunology · 2024Article
- IFNγ-secreting T cells that highly express IL-2 potently inhibit the growth of intracellularFrontiers in immunology · 2024Article
- Chicken γδ T cells proliferate upon IL-2 and IL-12 treatment and show a restricted receptor repertoire in cell culture.Frontiers in immunology · 2024Article
- Ovol1/2 loss-induced epidermal defects elicit skin immune activation and alter global metabolism.EMBO reports · 2023Article
- Adjunctive Zoledronate + IL-2 administrations enhance anti-tuberculosis Vγ2Vδ2 T-effector populations, and improve treatment outcome of multidrug-resistant tuberculosisEmerging microbes & infections · 2022Article
- SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or γδ T cells.PloS one · 2022Article
- Vγ2 x PD-L1, a Bispecific Antibody Targeting Both the Vγ2 TCR and PD-L1, Improves the Anti-Tumor Response of Vγ2Vδ2 T Cell.Frontiers in immunology · 2022Article
- Role of Vγ9vδ2 T lymphocytes in infectious diseases.Frontiers in immunology · 2022Review
- TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.Science advances · 2021Article
- Monocyte-dependent co-stimulation of cytokine induction in human γδ T cells by TLR8 RNA ligands.Scientific reports · 2021Article
- The role of donor-unrestricted T-cells, innate lymphoid cells, and NK cells in anti-mycobacterial immunity.Immunological reviews · 2021Review
- MIR337-3p Enhances Mycobacterial Pathogenicity Involving TLR4/MYD88 and STAT3 Signals, Impairing VDR Antimicrobial Response and Fast-Acting Immunity.Frontiers in immunology · 2021Article
- Genetics and Functional Mechanisms of STAT3 Polymorphisms in Human Tuberculosis.Frontiers in cellular and infection microbiology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 4 institutions in 2 countries.
Rui YangShanghai Key Lab of Tuberculosis, Clinic and Research Center of Tuberculosis, Shanghai Pulmonary Hospital, Institute for Advanced Study, Tongji University School of Medicine, Shanghai, China.
Lan YaoShanghai Key Lab of Tuberculosis, Clinic and Research Center of Tuberculosis, Shanghai Pulmonary Hospital, Institute for Advanced Study, Tongji University School of Medicine, Shanghai, China.
Ling ShenDepartment of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, IL, United States.
Wei ShaShanghai Key Lab of Tuberculosis, Clinic and Research Center of Tuberculosis, Shanghai Pulmonary Hospital, Institute for Advanced Study, Tongji University School of Medicine, Shanghai, China.
Robert L ModlinDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States.
Hongbo ShenShanghai Key Lab of Tuberculosis, Clinic and Research Center of Tuberculosis, Shanghai Pulmonary Hospital, Institute for Advanced Study, Tongji University School of Medicine, Shanghai, China.
Zheng W ChenDepartment of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine, Chicago, IL, United States.
Shanghai Pulmonary Hospital · CNIllinois College · USTongji University · CNUniversity of California, Los Angeles · US
Funding
MODEL OF AIDS VIRUS-RELATED PULMONARY TUBERCULOSISR01HL064560 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHEN, ZHENG W · 1999 to 2014
$9.5MSIV/MYCOBACTERIUM COINFECTIONR01RR013601 · NCRR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHEN, ZHENG W · 1998 to 2008
$4.4MAg-specific gamma delta T cells and immunity to TB/AIDS-related TBR01OD015092 · OD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHEN, ZHENG W · 2013 to 2017
$3.0MAnti-TB sterilizing immunity in immune and HIV+ individualsR01HL129887 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHEN, ZHENG W · 2015 to 2018
$2.1MNCRR NIH HHS R01 RR013601NHLBI NIH HHS R01 HL064560NHLBI NIH HHS R01 HL129887NIH HHS R01 OD015092
Abstract
While IL-12 plays a key role in differentiation of protective CD4
Indexed as
Cell DifferentiationCells, CulturedHumansInterleukin-12Intraepithelial LymphocytesLymphocyte ActivationMycobacterium tuberculosisOrganophosphatesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionSTAT4 Transcription FactorTh1 CellsT-Lymphocyte SubsetsTumor Necrosis Factor-alpha4-hydroxy-3-methyl-2-butenyl diphosphateInterleukin-12OrganophosphatesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSTAT4 protein, humanSTAT4 Transcription FactorTumor Necrosis Factor-alphaanti-tuberculosisdifferentiationIL-12proliferationVγ2Vδ2 T cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.