ReviewFrontiers in immunology2019
T Cell Receptor Expression Timing and Signal Strength in the Functional Differentiation of Invariant Natural Killer T Cells.
Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Eed-dependent histone modification orchestrates the iNKT cell developmental program alleviating liver injury.Frontiers in immunology · 2024Article
- The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRβ and TCRα Genes and Influences Development of αβ T Cell Lineages.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Alteration of circulating unconventional T cells in cerebral ischemia: an observational study.Scientific reports · 2022Observational
- Type 2 and Type 17 Invariant Natural Killer T Cells Contribute to Local Eosinophilic and Neutrophilic Inflammation and Their Function Is Regulated by Mucosal Microenvironment in Nasal Polyps.Frontiers in immunology · 2022Article
- Protein abundance of the cytokine receptor γc controls the thymic generation of innate-like T cells.Cellular and molecular life sciences : CMLS · 2021Article
- Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells.Nature communications · 2021Article
- The Mechanism of Stimulating and Mobilizing the Immune System Enhancing the Anti-Tumor Immunity.Frontiers in immunology · 2021Review
- The Timing and Abundance of IL-2Rβ (CD122) Expression Control ThymicFrontiers in immunology · 2021Article
- Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Recent advances in iNKT cell development.F1000Research · 2020Review
- Serpinb1a Is Dispensable for the Development and Cytokine Response of Invariant Natural Killer T Cell Subsets.Frontiers in immunology · 2020Article
- Reduction of Peripheral Blood iNKT and γδT Cells in Patients With Parkinson's Disease: An Observational Study.Frontiers in immunology · 2020Observational
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CD1d-restricted Vα14 invariant NKT (iNKT) cell lineage in mice (Vα24 in humans) represents an evolutionary conserved innate-like immune cell type that recognizes glycolipid antigens. Because of their unique ability to promptly secrete copious amounts of both pro-inflammatory and anti-inflammatory cytokines, typically produced by different T helper cell types, iNKT cells are implicated in the regulation of various pathologic conditions such as infection, allergy, autoimmune disease, maintenance of transplantation tolerance, and cancer. This striking multifaceted role in immune regulation is correlated with the presence of multiple functionally distinct iNKT cell subsets that can be distinguished based on the expression of characteristic surface markers and transcription factors. However, to date it, remains largely unresolved how this puzzling diversity of iNKT cell functional subsets emerges and what factors dictate the type of effector cell differentiation during the thymic differentiation considering the mono-specific nature of their T cell receptor (TCR) and their selecting molecule CD1d. Here, we summarize recent findings focusing on the role of TCR-mediated signaling and discuss possible mechanisms that may influence the sub-lineage choice of iNKT cells.
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