Evidence map›Paper›PMID 31080383›Full record

ArticleAdvanced functional materials2018

Nanostructured Lipid-based Films for Substrate Mediated Applications in Biotechnology.

Minjee Kang, Mohit Tuteja, Andrea Centrone, Daniel Topgaard, Cecilia Leal

Open access · greenAbstract read
In one paragraph

Article in Advanced functional materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Membrane-Inserting α‑Lipid Polymers: Understanding Lipid Membrane Insertion and Effect on Membrane Fluidity.Chemistry of materials : a publication of the American Chemical Society · 2025
    Article
  3. Article
  4. Article
  5. Preparation of Nanocomposite Biopolymer Films fromFoods (Basel, Switzerland) · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Polymer-Lipid Hybrid Materials.Chemical reviews · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Minjee KangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Mohit TutejaCenter for Nanoscale Science and Technology, National Institute of Standards and Technology, Gaithersburg, MD 20899, United States.
Andrea CentroneCenter for Nanoscale Science and Technology, National Institute of Standards and Technology, Gaithersburg, MD 20899, United States.
Daniel TopgaardDivision of Physical Chemistry, Center of Chemistry and Chemical Engineering, Lund University, Lund, Sweden.
Cecilia LealDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
National Institute of Standards and Technology · USUniversity of Illinois Urbana-Champaign · USLund University · SE

Funding

A New Paradigm in Nanomedicine: can structural interiors of nanoparticles regulate cellular delivery?DP2EB024377 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LEAL, CECILIA MARIA · 2016 to 2016
$2.3M
Intramural NIST DOC 9999-NISTNIBIB NIH HHS DP2 EB024377
6 · The paper itself

Abstract

Amphiphilic in nature, lipids spontaneously self-assemble into a range of nanostructures in the presence of water. Among lipid self-assembled structures, liposomes and supported lipid bilayers have long held scientific interest for their main applications in drug delivery and plasma membrane models, respectively. In contrast, lipid-based multi-layered membranes on solid supports only recently begun drawing scientists' attention. New studies on lipid films show that the stacking of multiple bilayers on a solid support yields interestingly complex features to these systems. Namely, multiple layers exhibit cooperative structural and dynamic behavior. In addition, the materials enable compartmentalization, templating, and enhanced release of several molecules of interest. Importantly, supported lipid phases exhibit long-range periodic nano-scale order and orientation that is tunable in response to a changing environment. Herein, we summarize current and pertinent understanding of lipid-based film research focusing on how unique structural characteristics enable the emergence of new applications in biotechnology including label-free biosensors, macroscale drug delivery, and substrate-mediated gene delivery. Our very recent contributions to lipid-based films, focusing on the structural characterization at the meso, nano, and molecular-scale, using Small-Angle X-ray Scattering, Atomic Force Microscopy, Photothermal Induced Resonance, and Solid-State NMR will be also highlighted.

Indexed as

lipid filmslipid-polymer hybridssolid-state NMRsubstrate-mediated deliverysupported membranes

Identifiers

PMID31080383
PMCPMC6508631
OpenAlexW2783360784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.