Evidence map›Paper›PMID 31080076›Full record

ArticleCell chemical biology2019

Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells.

Charles A Berdan, Raymond Ho, Haley S Lehtola, Milton To, Xirui Hu, Tucker R Huffman, Yana Petri, Chad R Altobelli, Sasha G Demeulenaere, James A Olzmann and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Charles A BerdanDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, University of California, Berkeley, Berkeley, CA 94720, USA.
Raymond HoDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Haley S LehtolaDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Milton ToDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Xirui HuDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Tucker R HuffmanDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Yana PetriDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, University of California, Berkeley, Berkeley, CA 94720, USA.
Chad R AltobelliDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
Sasha G DemeulenaereDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
James A OlzmannDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Thomas J MaimoneDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: maimone@berkeley.edu.
Daniel K NomuraDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Novartis-Berkeley Center for Proteomics and Chemistry Technologies, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: dnomura@berkeley.edu.
University of California, Berkeley · US

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MORELLO-FROSCH, RACHEL ADELE · 1987 to 2025
$74.6M
Chemical Probes to Study Formaldehyde BiologyR01ES028096 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2017 to 2026
$4.1M
Molecular Mechanisms of Lipid Droplet BiogenesisR01GM112948 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI OLZMANN, JAMES A · 2015 to 2024
$3.1M
Synthesis of Complex Terpenes From Simple Precursors: RenewalR01GM116952 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MAIMONE, THOMAS JOHN · 2016 to 2024
$2.7M
Annotating the Role of Dysregulated Inositol Phosphate Metabolism in Malignant CaR01CA172667 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI NOMURA, DANIEL · 2013 to 2017
$1.7M
NCI NIH HHS R01 CA172667NIEHS NIH HHS P42 ES004705NIEHS NIH HHS R01 ES028096NIGMS NIH HHS R01 GM112948NIGMS NIH HHS R01 GM116952
6 · The paper itself

Abstract

Parthenolide, a natural product from the feverfew plant and member of the large family of sesquiterpene lactones, exerts multiple biological and therapeutic activities including anti-inflammatory and anti-cancer effects. Here, we further study the parthenolide mechanism of action using activity-based protein profiling-based chemoproteomic platforms to map additional covalent targets engaged by parthenolide in human breast cancer cells. We find that parthenolide, as well as other related exocyclic methylene lactone-containing sesquiterpenes, covalently modify cysteine 427 of focal adhesion kinase 1 (FAK1), leading to impairment of FAK1-dependent signaling pathways and breast cancer cell proliferation, survival, and motility. These studies reveal a functional target exploited by members of a large family of anti-cancer natural products.

Indexed as

Biological ProductsBreast NeoplasmsCell Line, TumorCell MovementCell ProliferationCell SurvivalFemaleFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesHumansLactonesSesquiterpenesSignal TransductionTanacetum partheniumBiological ProductsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesLactonesmethylene-lactoneparthenolidePTK2 protein, humanSesquiterpenesABPPactivity-based protein profilingchemoproteomicscovalent ligandsFAK1focal adhesion kinase 1natural productsparthenolidePTK2

Identifiers

PMID31080076
PMCPMC6756182
OpenAlexW2952560816

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.