Evidence map›Paper›PMID 31080067›Full record

ArticleCell2019

Area-Specificity and Plasticity of History-Dependent Value Coding During Learning.

Ryoma Hattori, Bethanny Danskin, Zeljana Babic, Nicole Mlynaryk, Takaki Komiyama

Abstract read
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed.

  1. Population geometries in frontal cortex coordinate value-based decisions.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
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  5. Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Article
  7. Meta-learning is expressed through altered prefrontal cortical dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Cell-type-specific sustained value representations in the claustrum.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Review
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  14. Review
  15. Autism-associatedProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryoma HattoriNeurobiology Section, Center for Neural Circuits and Behavior, Department of Neurosciences, and Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: rhattori0204@gmail.com.
Bethanny DanskinNeurobiology Section, Center for Neural Circuits and Behavior, Department of Neurosciences, and Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA 92093, USA.
Zeljana BabicNeurobiology Section, Center for Neural Circuits and Behavior, Department of Neurosciences, and Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA 92093, USA.
Nicole MlynarykNeurobiology Section, Center for Neural Circuits and Behavior, Department of Neurosciences, and Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA 92093, USA.
Takaki KomiyamaNeurobiology Section, Center for Neural Circuits and Behavior, Department of Neurosciences, and Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: tkomiyama@ucsd.edu.

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Derek Stuart Welsbie · 2012 to 2026
$10.3M
Neurosciences Graduate Training ProgramT32NS061847 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Brenda L Bloodgood · 2008 to 2026
$7.7M
Cortical Control of Motor LearningR01NS091010 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIYAMA, TAKAKI · 2015 to 2024
$3.7M
Network basis of action selectionU01NS094342 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI KOMIYAMA, TAKAKI, KREITZER, ANATOL · 2015 to 2017
$3.0M
Experience-driven plasticity of olfactory bulb odor representationsR01DC014690 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIYAMA, TAKAKI · 2015 to 2019
$1.9M
Experience-driven plasticity of visual circuitsR01EY025349 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIYAMA, TAKAKI · 2015 to 2019
$1.6M
Training Program in Quantitative Integrative BiologyT32GM127235 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HWA, TERENCE · 2018 to 2022
$1.3M
Elucidating the neural substrate for value-based decision.F31MH116613 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DANSKIN, BETHANNY · 2018 to 2020
$114k
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY025349NIDCD NIH HHS R01 DC014690NIGMS NIH HHS T32 GM127235NIMH NIH HHS F31 MH116613NINDS NIH HHS R01 NS091010NINDS NIH HHS T32 NS061847NINDS NIH HHS U01 NS094342
6 · The paper itself

Abstract

Decision making is often driven by the subjective value of available options, a value which is formed through experience. To support this fundamental behavior, the brain must encode and maintain the subjective value. To investigate the area specificity and plasticity of value coding, we trained mice in a value-based decision task and imaged neural activity in 6 cortical areas with cellular resolution. History- and value-related signals were widespread across areas, but their strength and temporal patterns differed. In expert mice, the retrosplenial cortex (RSC) uniquely encoded history- and value-related signals with persistent population activity patterns across trials. This unique encoding of RSC emerged during task learning with a strong increase in more distant history signals. Acute inactivation of RSC selectively impaired the reward-history-based behavioral strategy. Our results indicate that RSC flexibly changes its history coding and persistently encodes value-related signals to support adaptive behaviors.

Indexed as

AnimalsBehavior, AnimalDecision MakingGyrus CinguliLearningMiceMice, TransgenicNeuronal PlasticityNeuronsdecision makinghistorymotor cortexoptogeneticsplasticityposterior parietal cortexretrosplenial cortexsensory cortextwo-photonvalue

Identifiers

PMID31080067
PMCPMC6663310

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.