Evidence map›Paper›PMID 31080062›Full record

ArticleCell2019

Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter.

Yan Wang, Nam X Nguyen, Ji She, Weizhong Zeng, Yi Yang, Xiao-Chen Bai, Youxing Jiang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Perturbation of mitochondrial CaStress biology · 2026
    Article
  8. Article
  9. Mitochondrial CaCommunications biology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. TMEM65 functions as the mitochondrial NaNature cell biology · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yan WangHoward Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Nam X NguyenHoward Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ji SheHoward Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Weizhong ZengHoward Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yi YangHoward Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiao-Chen BaiDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: xiaochen.bai@utsouthwestern.edu.
Youxing JiangHoward Hughes Medical Institute and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: youxing.jiang@utsouthwestern.edu.
Howard Hughes Medical Institute · USSouthwestern Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

Structural mechanisms of ion selectivity and gating in tetrameric cation channelsR01GM079179 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, YOUXING · 2007 to 2019
$3.5M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM079179
6 · The paper itself

Abstract

Mitochondrial calcium uptake is crucial to the regulation of eukaryotic Ca

Indexed as

Calcium ChannelsHEK293 CellsHumansIon Channel GatingMultiprotein ComplexesProtein DomainsProtein MultimerizationProtein Structure, SecondaryCalcium Channelsmitochondrial calcium uniporterMultiprotein ComplexesSMDT1 protein, humancalcium channelintracellular calcium signalingmitochondrial calcium uniporter

Identifiers

PMID31080062
PMCPMC6597010
OpenAlexW2943983020

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.