Evidence map›Paper›PMID 31080027›Full record

Observational studyAnnals of emergency medicine2019

Clinical Benefit of Hospitalization for Older Adults With Unexplained Syncope: A Propensity-Matched Analysis.

Marc A Probst, Erica Su, Robert E Weiss, Annick N Yagapen, Susan E Malveau, David H Adler, Aveh Bastani, Christopher W Baugh, Jeffrey M Caterino, Carol L Clark and 9 more

Open access · greenAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Annals of emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Shared Decision Making for Syncope in the Emergency Department: A Randomized Controlled Feasibility Trial.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2020
    Trial
  2. Observational
  3. Article
  4. Article
  5. Application of five risk stratification tools for syncope in older adults.The Journal of international medical research · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Lack of benefit from hospitalization in patients with syncope: A propensity analysis.Journal of the American College of Emergency Physicians open · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 15 institutions in 1 country.

Marc A ProbstDepartment of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: mprobst@gmail.com.
Erica SuDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA.
Robert E WeissDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA.
Annick N YagapenCenter for Policy and Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health & Science University, Portland, OR.
Susan E MalveauCenter for Policy and Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health & Science University, Portland, OR.
David H AdlerDepartment of Emergency Medicine, University of Rochester, Rochester, NY.
Aveh BastaniDepartment of Emergency Medicine, William Beaumont Hospital-Troy, Troy, MI.
Christopher W BaughDepartment of Emergency Medicine, Brigham & Women's Hospital, Boston, MA.
Jeffrey M CaterinoDepartment of Emergency Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Carol L ClarkDepartment of Emergency Medicine, William Beaumont Hospital-Royal Oak, Royal Oak, MI.
Deborah B DiercksDepartment of Emergency Medicine, University of Texas-Southwestern, Dallas, TX.
Judd E HollanderDepartment of Emergency Medicine, Thomas Jefferson University Hospital, Philadelphia, PA.
Bret A NicksDepartment of Emergency Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Daniel K NishijimaDepartment of Emergency Medicine, UC Davis School of Medicine, Sacramento, CA.
Manish N ShahDepartment of Emergency Medicine, University of Wisconsin-Madison, Madison, WI.
Kirk A StifflerDepartment of Emergency Medicine, Northeastern Ohio Medical University, Rootstown, OH.
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.
Scott T WilberDepartment of Emergency Medicine, Northeastern Ohio Medical University, Rootstown, OH.
Benjamin C SunCenter for Policy and Research in Emergency Medicine, Department of Emergency Medicine, Oregon Health & Science University, Portland, OR.
Oregon Health & Science University · USNortheast Ohio Medical University · USUniversity of California, Los Angeles · USBeaumont Hospital, Royal Oak · USBeaumont Hospital, Troy · USBrigham and Women's Hospital · USIcahn School of Medicine at Mount Sinai · USThe Ohio State University Wexner Medical Center · USThe University of Texas Southwestern Medical Center · USThomas Jefferson University Hospital · USUniversity of California, Davis · USUniversity of Rochester · USUniversity of Wisconsin–Madison · USVanderbilt University Medical Center · USWake Forest University · US

Funding

Improving Syncope Risk Stratification in Older AdultsR01HL111033 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SUN, BENJAMIN C · 2013 to 2017
$3.8M
SYNDICARE: Syncope Decision Aid for Emergency CareK23HL132052 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PROBST, MARC · 2016 to 2019
$678k
NHLBI NIH HHS K23 HL132052NHLBI NIH HHS R01 HL111033
6 · The paper itself

Abstract

STUDY

objectiveMany adults with syncope are hospitalized solely for observation and testing. We seek to determine whether hospitalization versus outpatient management for older adults with unexplained syncope is associated with a reduction in postdisposition serious adverse events at 30 days.

methodsWe performed a propensity score analysis using data from a prospective, observational study of older adults with unexplained syncope or near syncope who presented to 11 emergency departments (EDs) in the United States. We enrolled adults (≥60 years) who presented with syncope or near syncope. We excluded patients with a serious diagnosis identified in the ED. Clinical and laboratory data were collected on all patients. The primary outcome was rate of post-ED serious adverse events at 30 days.

resultsWe enrolled 2,492 older adults with syncope and no serious ED diagnosis from April 2013 to September 2016. Mean age was 73 years (SD 8.9 years), and 51% were women. The incidence of serious adverse events within 30 days after the index visit was 7.4% for hospitalized patients and 3.19% for discharged patients, representing an unadjusted difference of 4.2% (95% confidence interval 2.38% to 6.02%). After propensity score matching on risk of hospitalization, there was no statistically significant difference in serious adverse events at 30 days between the hospitalized group (4.89%) and the discharged group (2.82%) (risk difference 2.07%; 95% confidence interval -0.24% to 4.38%).

conclusionIn our propensity-matched sample of older adults with unexplained syncope, for those with clinical characteristics similar to that of the discharged cohort, hospitalization was not associated with improvement in 30-day serious adverse event rates.

Indexed as

AgedAged, 80 and overEmergency Service, HospitalFemaleHospitalizationHumansIncidenceMaleMedically Unexplained SymptomsMiddle AgedPatient DischargePropensity ScoreProspective StudiesRisk AssessmentSyncopeUnited States

Identifiers

PMID31080027
PMCPMC6650347
OpenAlexW2944289238

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.