ArticleThe Psychiatric quarterly2019
Cognitive Impairments in First-Episode Drug-Naïve Versus Medicated Depressive Patients: RBANS in a Chinese Population.
Article in The Psychiatric quarterly, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurocognitive deficits in depression: a systematic review of cognitive impairment in the acute and remitted state.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Oxidative stress and cognitive function in Chinese patients with major depressive disorder: the mediating role of depression severity.BMC psychiatry · 2025Article
- The sex-specific relationship of ghrelin and cognition in Chinese han first-episode drug-naive major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Contribution of physiological dynamics in predicting major depressive disorder severity.Psychophysiology · 2025Article
- Neurocognitive Changes in Patients with Post-COVID Depression.Journal of clinical medicine · 2024Article
- Association between increased serum interleukin-8 levels and improved cognition in major depressive patients with SSRIs.BMC psychiatry · 2023Article
- Status and Factors of Cognitive Function Among Older Adults in Urban China.Frontiers in psychology · 2021Article
- The MATRICS Consensus Cognitive Battery: Psychometric Properties of the Chinese Version in Young Patients With Major Depression Disorder.Frontiers in psychiatry · 2021Article
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Authors and funding
9 authors.
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Abstract
Cognitive deficits are a core feature of major depressive disorder (MDD). However, there are no previous studies that directly compare cognitive performance between first-episode drug-naive depressive patients (FDDP) and medicated depressive patients (MDP). Therefore, the aim of this study was to investigate whether there were the differences in cognitive functions between FDDP and MDP. Sixty-two FDDP, 111 MDP and 90 healthy controls were enrolled in a Chinese population. Cognitive functions were assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). There were the differences in the RBANS total score (F = 26.55, p < 0.001), subscales of immediate memory (F = 3.95, p = 0.02), language (F = 54.11, p < 0.001) and delayed memory (F = 11.19, p = 0.001) among the three groups after controlling for gender, education, smoking and body mass index (BMI). These differences in the RBANS total score, subscales of language and delayed memory passed the Bonferroni corrections (all, p < 0.05). Compared to healthy controls, FDDP and MDP had poorer cognitive performance including the RBANS total score, and subscales of language and delayed memory (all, p < 0.05) after controlling for the variables. FDDP experienced greater language deficits than MDP (p < 0.05) after controlling for the variables. Education was correlated with the language score in FDDP (r = 0.61, p < 0.001). Multivariate regression analysis indicated that education was an independent contributor to the language score in FDDP (ß = 3.11, t = 5.48, p < 0.001). Our findings indicated that FDDP had poorer language performance than MDP. Moreover, education could influence the language performance in FDDP.
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