Evidence map›Paper›PMID 31079266›Full record

ArticleJournal of assisted reproduction and genetics2019

PCSK9 and Lp(a) levels of children born after assisted reproduction technologies.

Charalambos Vlachopoulos, Ioanna Kosteria, Sophia Sakka, Alexandra Gkourogianni, Dimitrios Terentes-Printzios, Iosif Koutagiar, Ioannis Skoumas, Antigoni Miliou, Ioannis Papassotiriou, Vasiliki Gardikioti and 4 more

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Article in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Charalambos Vlachopoulos1st Department of Cardiology, Hypertension and Cardiometabolic Syndrome Unit, National and Kapodistrian University of Athens, Hippokrateion Hospital, 114 Vasilissis Sofias avenue, Athens, Greece. cvlachop@otenet.gr.
Ioanna Kosteria
Sophia Sakka
Alexandra Gkourogianni
Dimitrios Terentes-Printzios1st Department of Cardiology, Hypertension and Cardiometabolic Syndrome Unit, National and Kapodistrian University of Athens, Hippokrateion Hospital, 114 Vasilissis Sofias avenue, Athens, Greece.
Iosif Koutagiar1st Department of Cardiology, Hypertension and Cardiometabolic Syndrome Unit, National and Kapodistrian University of Athens, Hippokrateion Hospital, 114 Vasilissis Sofias avenue, Athens, Greece.
Ioannis Skoumas1st Department of Cardiology, Hypertension and Cardiometabolic Syndrome Unit, National and Kapodistrian University of Athens, Hippokrateion Hospital, 114 Vasilissis Sofias avenue, Athens, Greece.
Antigoni Miliou1st Department of Cardiology, Hypertension and Cardiometabolic Syndrome Unit, National and Kapodistrian University of Athens, Hippokrateion Hospital, 114 Vasilissis Sofias avenue, Athens, Greece.
Ioannis PapassotiriouDepartment of Clinical Biochemistry, "Aghia Sophia" Children's Hospital, Athens, Greece.
Vasiliki Gardikioti1st Department of Cardiology, Hypertension and Cardiometabolic Syndrome Unit, National and Kapodistrian University of Athens, Hippokrateion Hospital, 114 Vasilissis Sofias avenue, Athens, Greece.
Dimitrios Loutradis1st Department of Gynecology and Obstetrics, National and Kapodistrian University of Athens, Alexandra Sophia Children's Hospital, Athens, Greece.
George Chrousos1st Department of Pediatrics, Division of Endocrinology, Diabetes and Metabolism, National and Kapodistrian University of Athens, "Agia Sophia" Children's Hospital, Athens, Greece.
Christina Kanaka-Gantenbein1st Department of Pediatrics, Division of Endocrinology, Diabetes and Metabolism, National and Kapodistrian University of Athens, "Agia Sophia" Children's Hospital, Athens, Greece.
Dimitrios Tousoulis1st Department of Cardiology, Hypertension and Cardiometabolic Syndrome Unit, National and Kapodistrian University of Athens, Hippokrateion Hospital, 114 Vasilissis Sofias avenue, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeProprotein convertase subtilisin/kexin type 9 (PCSK9) and lipoprotein (a) (Lp[a]) levels are associated with cardiovascular risk. To investigate PCSK9 and Lp(a) levels of children born after assisted reproduction technologies (ART) compared with naturally conceived (NC) controls.

methodsIn this exposure-matched cohort study, 73 racial-, sex-, and age-matched children (mean age 98 ± 35 months) of ART (intracytoplasmic sperm injection [ICSI] n = 33, classic in vitro fertilization [IVF] n = 40) and 73 NC children were assessed. Blood lipid profile, including PCSK9 and Lp(a) levels, was measured. Children were grouped according to age (< 8 years, 8-10 years, ≥ 10 years).

resultsIn the overall population, PCSK9 levels were related to total cholesterol, low-density lipoprotein, and systolic blood pressure, while Lp(a) levels were related to age, apolipoprotein-B, birth weight, height, waist-to-hip ratio, insulin resistance, insulin, and high-sensitivity C-reactive protein. No significant differences were observed regarding lipid biomarkers between ART and NC children. However, a significant interaction was found between age groups and conception method (p < 0.001) showing that PCSK9 levels increase with age in ART children, while they decline with age in NC offspring. IVF children showed higher levels of adjusted mean Lp(a) than ICSI (13.5 vs. 6.8 mg/dl, p = 0.010) and NC children (12.3 vs. 8.3 mg/dl, p = 0.048).

conclusionsWe show that PCSK9 levels increase with age in ART children, indicating a gradual deterioration of lipidemic profile that could lead to increased cardiovascular risk. Moreover, our results indicate that ART method may be of importance given that classic IVF is associated with higher levels of Lp(a).

Indexed as

BiomarkersCardiovascular DiseasesChildChild, PreschoolC-Reactive ProteinFemaleFertilization in VitroHumansInsulin ResistanceLipoprotein(a)MaleProprotein Convertase 9Reproductive Techniques, AssistedRisk FactorsSperm Injections, IntracytoplasmicBiomarkersC-Reactive ProteinLipoprotein(a)PCSK9 protein, humanProprotein Convertase 9AgeAssisted reproduction technologiesCardiovascular riskIn vitro fertilizationLipoprotein (a)PCSK9

Identifiers

PMID31079266
PMCPMC6603255

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.