Observational studyClinical oral investigations2020
Assessment of early discomfort and wound healing outcomes after periodontal surgery with and without enamel matrix derivative: an observational retrospective case-control study.
Observational study in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Long-term stability of adjunctive use of enamel matrix protein derivative on porcine-derived xenograft for the treatment of one-wall intrabony defects: A 4-year extended follow-up of a randomized controlled trial.Journal of periodontology · 2022Trial
- Effectiveness of a nutraceutical agent in the non-surgical periodontal therapy: a randomized, controlled clinical trial.Clinical oral investigations · 2021Trial
- Tunnel technique with enamel matrix derivative in addition to subepithelial connective tissue graft compared with connective tissue graft alone for the treatment of multiple gingival recessions: a randomized clinical trial.Clinical oral investigations · 2020Trial
- Adjunctive use of enamel matrix derivatives to porcine-derived xenograft for the treatment of one-wall intrabony defects: Two-year longitudinal results of a randomized controlled clinical trial.Journal of periodontology · 2020Trial
- Modified tunnel technique with and without enamel matrix derivative for deep and narrow gingival recession in the mandibular anterior region: a 3-year longitudinal and retrospective cohort population-based study.Journal of periodontal & implant science · 2025Article
- Incidence and risk factors of postoperative complications following periodontal flap surgery: a retrospective study.Frontiers in dental medicine · 2025Article
- Platelet-Rich Fibrin in Non-Surgical Periodontal Therapy: A Split-Mouth Randomized Controlled Clinical Trial.Dentistry journal · 2024Article
- Porcine-derived soft block bone substitutes for the treatment of severe class II furcation-involved mandibular molars: a prospective controlled follow-up study.Journal of periodontal & implant science · 2023Article
- Enamel Matrix Derivatives as an Adjunct to Alveolar Ridge Preservation-A Systematic Review.Dentistry journal · 2023Review
- Salivary Tests: A New Personalized Approach for the Early Diagnosis of Oral and Periodontal Diseases.Journal of personalized medicine · 2022Article
- Augmentation Stability of Guided Bone Regeneration for Peri-Implant Dehiscence Defects with L-shaped Porcine-Derived Block Bone Substitute.Materials (Basel, Switzerland) · 2021Article
- Effectiveness of porcine-derived xenograft with enamel matrix derivative for periodontal regenerative treatment of intrabony defects associated with a fixed dental prosthesis: a 2-year follow-up retrospective study.Journal of periodontal & implant science · 2021Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe aim of this study was to evaluate and compare early postoperative discomfort and wound healing outcomes between patients who underwent periodontal surgery with and without enamel matrix derivative (EMD), using retrospective questionnaires and postoperative clinical examinations. MATERIALS AND
methodsAll enrolled patients filled out the self-report questionnaire after suture removal. The severity and duration of subjective pain and swelling were evaluated using visual analog scale (VAS) scores and wound healing parameters (dehiscence/fenestration, spontaneous bleeding, persistent swelling, and ulceration). Chi-squared tests, two-tailed independent t tests, analysis of variance, and multiple logistic regression analysis were performed to identify significant differences between the two groups (surgery with EMD and surgery without EMD).
resultsThe severity of pain and swelling did not differ between patients who underwent surgery with and without EMD, but the durations of pain (P < 0.001) and swelling (P = 0.019) were significantly lower in patients who underwent surgery with EMD. Multivariate analysis with adjustment for confounding variables showed that wound healing outcomes including dehiscence/fenestration, spontaneous bleeding, and ulceration did not differ significantly between the two groups, and only persistent swelling showed significant differences (odds ratio 4.03, 95% CI 1.17-13.78; P = 0.026).
conclusionsNo difference was observed in the severity of early postoperative discomfort and wound healing outcomes between patients who underwent surgery with and without EMD, but shorter durations of postoperative pain and swelling were evident in patients who underwent surgery with EMD. CLINICAL RELEVANCE: Adjunctive EMD used in periodontal surgery has clinical advantages for reducing the durations of postoperative pain and swelling.
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