Evidence map›Paper›PMID 31079185›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2019

Diffuse osteosclerosis as a presentation of recurrent breast cancer: role of endothelin 1.

K G Zarnecki, J Kristianto, J Charlson, B Wilson, R D Blank, J L Shaker

Open access · bronzeAbstract readCase Reports
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

K G ZarneckiDepartment of Medicine (Endocrinology), Medical College of Wisconsin, Milwaukee, WI, USA.
J KristiantoDepartment of Medicine (Endocrinology), Medical College of Wisconsin, Milwaukee, WI, USA.
J CharlsonDepartment of Medicine (Hematology and Oncology), Medical College of Wisconsin, Milwaukee, WI, USA.
B WilsonDepartment of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA.
R D BlankDepartment of Medicine (Endocrinology), Medical College of Wisconsin, Milwaukee, WI, USA.
J L ShakerDepartment of Medicine (Endocrinology), Medical College of Wisconsin, Milwaukee, WI, USA. joseph.shaker@froedtert.com.ORCID http://orcid.org/0000-0002-6266-1029
Medical College of Wisconsin · USFroedtert Hospital · USUniversity of Wisconsin–Madison · US

Funding

National Institutes of Health AR54753
6 · The paper itself

Abstract

We report a 46-yr-old woman with a history of breast cancer who presented with diffuse myalgias, bone pain, and osteosclerosis. She was found to have recurrent breast cancer producing endothelin-1.

introductionAcquired osteosclerosis can be caused by various disorders. Endothelin -1 is believed to contribute to osteosclerosis caused by breast cancer.

methodsAlthough the bone marrow biopsy did not reveal breast cancer, she developed skin lesions consistent with metastatic breast cancer. She ultimately died from progressive disease. At autopsy immunohistochemistry for endothelin-1 was performed on a section from the L5 vertebral body.

resultsThe section from the L5 vertebral body showed small foci of cells consistent with metastatic carcinoma and a prominent sclerotic response. Immunohistochemistry for endothelin-1 was strongly positive.

conclusionsRecurrent breast cancer may present with diffuse osteosclerosis. Endothelin-1 may be a paracrine factor responsible for increased bone formation and osteosclerosis.

Indexed as

AdenocarcinomaBone NeoplasmsBreast NeoplasmsEndothelin-1Fatal OutcomeFemaleHumansMiddle AgedOsteosclerosisRadiographySkin NeoplasmsEndothelin-1Bone metastasesBreast cancerEndothelin 1Osteosclerosis

Identifiers

PMID31079185
OpenAlexW2944409986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.