Evidence map›Paper›PMID 31079115›Full record

ArticleObesity facts2019

Decreased Leptin Is Associated with Alterations in Thyroid-Stimulating Hormone Levels after Roux-en-Y Gastric Bypass Surgery in Obese Euthyroid Patients with Type 2 Diabetes.

Haoyong Yu, Qing Li, Mingliang Zhang, Fangyuan Liu, Jiemin Pan, Yinfang Tu, Junxi Lu, Pin Zhang, Junfeng Han, Weiping Jia and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity facts, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  4. Observational
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  15. Metabolic surgery in China: present and future.Journal of molecular cell biology · 2021
    Article
  16. Barocrinology: The Endocrinology of Obesity from Bench to Bedside.Medical sciences (Basel, Switzerland) · 2020
    Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Haoyong YuDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, affiliated to Shanghai Jiao Tong University, Shanghai, China.
Qing LiDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, affiliated to Shanghai Jiao Tong University, Shanghai, China.
Mingliang ZhangDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, affiliated to Shanghai Jiao Tong University, Shanghai, China.
Fangyuan LiuDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, affiliated to Shanghai Jiao Tong University, Shanghai, China.
Jiemin PanDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, affiliated to Shanghai Jiao Tong University, Shanghai, China.
Yinfang TuDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, affiliated to Shanghai Jiao Tong University, Shanghai, China.
Junxi LuDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, affiliated to Shanghai Jiao Tong University, Shanghai, China.
Pin ZhangDepartment of General Surgery, Shanghai Sixth People's Hospital, affiliated to Shanghai Jiao Tong University, Shanghai, China.
Junfeng HanDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, affiliated to Shanghai Jiao Tong University, Shanghai, China.
Weiping JiaDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, affiliated to Shanghai Jiao Tong University, Shanghai, China.
Yuqian BaoDepartment of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, affiliated to Shanghai Jiao Tong University, Shanghai, China, yqbao@sjtu.edu.cn.
Shanghai Clinical Research Center · CNShanghai Jiao Tong University · CNShanghai Sixth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeptin has been shown to stimulate the hypothalamus-pituitary-thyroid (HPT) axis in vivo and vitro. Its role in thyroid axis regulation after weight loss induced by bariatric surgery is still unknown. The aim of this study was to evaluate the influence of leptin on weight loss and thyroid function variation induced by Roux-en-Y gastric bypass (RYGB) surgery in euthyroid individuals with obesity and type 2 diabetes mellitus (T2DM).

methods65 Chinese individuals with obesity and T2DM who underwent RYGB, and 27 healthy volunteers were enrolled in this retrospective study. Participants were evaluated for changes in anthropometric parameters, metabolic indexes, thyroid function, and leptin levels before and 12 months after surgery.

resultsAfter RYGB, all of these patients experienced significant weight reduction and improved glucose control. Metabolic parameters were significantly ameliorated after surgery compared with baseline. Thyroid hormones including free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) declined in parallel. Median (IQR) plasma leptin levels decreased from 33.7 ng/mL (17.9-63.1) to 10.3 ng/mL (4.0-18.5). Pearson correlation analysis showed that TSH was significantly positively correlated with body mass index, C-reactive protein (CRP), and leptin. Multiple stepwise linear regression indicated that leptin and CRP were independent factors affecting TSH. The β coefficients were 0.38 (p = 0.001) and 0.32 (p = 0.004), respectively. There was a significant positive correlation between ΔTSH and Δleptin (r = 0.33, p = 0.01).

conclusionDecreased or normalized TSH levels after weight loss induced by RYGB might be mediated by the decline in leptin. There could be cross talk between adipose tissue and the HPT axis.

Indexed as

Gastric BypassAdultBariatric SurgeryBody Mass IndexCase-Control StudiesDiabetes Mellitus, Type 2FemaleHumansLeptinMaleMiddle AgedObesityRetrospective StudiesThyroid GlandThyrotropinWeight LossLeptinThyrotropinBariatric surgeryLeptinThyroid-stimulating hormone

Identifiers

PMID31079115
PMCPMC6696777
OpenAlexW2943986551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.