ArticleBMJ case reports2019
False-positive serologies for acute hepatitis A and autoimmune hepatitis in a patient with acute Epstein-Barr virus infection.
Article in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Hepatitis A virus infection.Nature reviews. Disease primers · 2023Review
- Sporadic Hepatitis A Virus PCR False-Positive Results Observed during Reflex Testing of Serum Samples Previously Tested for Anti-HAV Antibodies and Caused by Contamination with HAV RNA Present in the Reagents of the Commercial Anti-HAV Immunoassay.Microbiology spectrum · 2023Article
- [Clinical features of Epstein-Barr virus infection associated to liver injury in adolescents and adults].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021Article
- False positive anti-hepatitis A virus immunoglobulin M in autoimmune hepatitis/primary biliary cholangitis overlap syndrome: A case report.World journal of clinical cases · 2021Article
- Atypical case of syphilitic hepatitis.BMJ case reports · 2021Article
- Sustained false-positive results for hepatitis A virus immunoglobulin M: A case report and literature review.Open medicine (Warsaw, Poland) · 2021Article
- Paediatrics: how to manage pharyngitis in an era of increasing antimicrobial resistance.Drugs in context · 2021Review
- Epidemiological Characteristics and Clinical Manifestations of Hepatitis E in a Tertiary Hospital in China: A Retrospective Study.Frontiers in microbiology · 2021Article
- False-positive SARS-CoV-2 serology in 3 children with Kawasaki disease.Diagnostic microbiology and infectious disease · 2020Article
- Hepatitis A virus infection in an HIV-positive man with previously confirmed immunity against hepatitis A virus.Clinical journal of gastroenterology · 2020Article
- Acute hepatitis due to infectious mononucleosis.BMJ case reports · 2019Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute hepatitis remains a diagnostic challenge, and numerous infectious, metabolic and autoimmune diseases need to be effectively excluded. We present a case of a young woman with malaise, fever, jaundice and deranged liver function tests. Testing for Epstein-Barr virus (EBV) virus capsid antigen IgM/IgG was positive. Total IgG was elevated, along with positive serology for anti-hepatitis A virus (HAV)-IgM, antinuclear antibodies (ANAs) and soluble liver antigen (SLA) leading to the differential diagnosis of acute hepatitis A and autoimmune hepatitis. No specific treatment was started and liver function gradually improved. At week 4, HAV IgG and IgM were negative. At month 4, ANA and SLA were negative and total IgG normalised; EBV nuclear antigen became positive. Testing for EBV is an investigation required at baseline in acute hepatitis and physicians should carefully evaluate serological results, including those for viral and autoimmune hepatitis that may be falsely positive in infectious mononucleosis.
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