ArticleiScience2019
Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune Function.
Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 94 citations in OpenAlex.
- A review of skin microbiome and new challenges to cosmetic microbiome-friendly formulations.International journal of cosmetic science · 2026Review
- What's New in Photoprotection?American journal of clinical dermatology · 2026Review
- SkinApplied and environmental microbiology · 2026Article
- Microbial Dysbiosis in Photodermatoses: Formation, Pathogenesis and Intervention Strategies.Current issues in molecular biology · 2026Review
- Ultraviolet radiation reshapes the metabolome of skin commensal bacteria, influencing AhR signaling and barrier function.Applied and environmental microbiology · 2026Article
- Preliminary characterization of the skin microbiota in basal cell carcinoma: An exploratory pilot study in Korean patients.Journal of microbiology (Seoul, Korea) · 2026Article
- The human skin microbiome remains unchanged after 24 h of sunscreen application.Applied and environmental microbiology · 2026Article
- Biological Roles of Melanin and Natural Product-Derived Approaches for Its Modulation.International journal of molecular sciences · 2026Review
- Ultraviolet Radiation and the Skin Microbiome: Dose-Dependent Effects and Consequences for Epidermal Barrier Integrity.Clinical, cosmetic and investigational dermatology · 2026Review
- Tertiary Lymphoid Organs at the Center Stage of Skin's Humoral Immunity.Immunological reviews · 2025Review
- Advances in the Relationship Between Skin Tumor Occurrence, Development, Prognosis, and the Human Microbiome.Current microbiology · 2025Review
- The Skin Microbiome, Microbial Metabolites and the Epidermal Response to Ultraviolet Radiation-Towards Next Generation Suncare.Experimental dermatology · 2025Review
- Beneficial health effects of ultraviolet radiation: expert review and conference report.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Review
- The Skin Microbiome: A New Key Player in Melanoma, From Onset to Metastatic Stage.Pigment cell & melanoma research · 2025Review
- Review
- Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota.Molecules (Basel, Switzerland) · 2024Article
- Current Approaches to Prevent or Reverse Microbiome Dysbiosis in Chronic Inflammatory Rheumatic Diseases.Mediterranean journal of rheumatology · 2024Review
- Spectral characterization of a blue light-emitting micro-LED platform on skin-associated microbial chromophores.Biomedical optics express · 2024Article
- Modulation of the skin microbiome in cutaneous T-cell lymphoma delays tumour growth and increases survival in the murine EL4 model.Frontiers in immunology · 2024Article
- Ionizing radiation improves skin bacterial dysbiosis in cutaneous T-cell lymphoma.Frontiers in immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The skin is colonized by a diverse microbiome intricately involved in various molecular and cellular processes within the skin and beyond. UV radiation is known to induce profound changes in the skin and modulate the immune response. However, the role of the microbiome in UV-induced immune suppression has been overlooked. By employing the standard model of contact hypersensitivity (using germ-free mice) we found diminished UV-induced systemic immune suppression in the presence of microbiome. Upon UV exposure, we found enhanced epidermal hyperplasia and neutrophilic infiltration in the presence and enhanced numbers of mast cells and monocyte or macrophages in the absence of microbiome. Transcriptome analysis revealed a predominant expression of cytokine genes related to pro-inflammatory milieu in the presence versus immunosuppressive milieu (with increased interleukin-10) in the absence of microbiome. Collectively, microbiome abrogates the immunosuppressive response to UV by modulating gene expression and cellular microenvironment of the skin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.