Evidence map›Paper›PMID 31078932›Full record

ArticleVirology2019

Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus.

Manuel Kanitz, Sandra Blanck, Andreas Heine, Anastasia A Gulyaeva, Alexander E Gorbalenya, John Ziebuhr, Wibke E Diederich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Structural similarities between SARS-CoV2 3CLFrontiers in chemistry · 2022
    Article
  4. A nidovirus perspective on SARS-CoV-2.Biochemical and biophysical research communications · 2021
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manuel KanitzCenter for Tumor Biology and Immunology, Philipps University, Marburg, Germany; Institute of Pharmaceutical Chemistry, Philipps University, Marburg, Germany.
Sandra BlanckInstitute of Medical Virology, Justus Liebig University, Giessen, Germany.
Andreas HeineInstitute of Pharmaceutical Chemistry, Philipps University, Marburg, Germany.
Anastasia A GulyaevaDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
Alexander E GorbalenyaDepartment of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
John ZiebuhrInstitute of Medical Virology, Justus Liebig University, Giessen, Germany. Electronic address: john.ziebuhr@viro.med.uni-giessen.de.
Wibke E DiederichCenter for Tumor Biology and Immunology, Philipps University, Marburg, Germany; Institute of Pharmaceutical Chemistry, Philipps University, Marburg, Germany. Electronic address: wibke.diederich@staff.uni-marburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cavally virus (CavV) is a mosquito-borne plus-strand RNA virus in the family Mesoniviridae (order Nidovirales). We present X-ray structures for the CavV 3C-like protease (3CL

Indexed as

Amino Acid MotifsAmino Acid SequenceAnimalsBinding SitesCatalysisCrystallography, X-RayCulicidaeCysteine ProteasesNidoviralesSequence AlignmentSubstrate SpecificityViral ProteinsCysteine ProteasesViral Proteins3C-like proteaseActive site of chymotrypsin-like proteasesCoronavirusCrystal structureInvertebrate RNA virusMesonivirus

Identifiers

PMID31078932
PMCPMC7111312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.