ArticleGrowth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
Characterization of an intestine-specific GH receptor knockout (IntGHRKO) mouse.
Article in Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Microbiota-gut-brain axis and neuroendocrine pathways underlie divergent mechanisms of intermittent and continuous theta-burst stimulation in autism spectrum disorder.Cellular and molecular life sciences : CMLS · 2026Article
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- Excess Growth Hormone Alters the Male Mouse Gut Microbiome in an Age-dependent Manner.Endocrinology · 2022Article
- Preventing Bacterial Translocation in Patients with Leaky Gut Syndrome: Nutrition and Pharmacological Treatment Options.International journal of molecular sciences · 2022Review
- Characteristics of Gut Microbiota in Patients with GH-Secreting Pituitary Adenoma.Microbiology spectrum · 2022Article
- Mice with gene alterations in the GH and IGF family.Pituitary · 2022Review
- Growth hormone alters gross anatomy and morphology of the small and large intestines in age- and sex-dependent manners.Pituitary · 2022Article
- Mouse models of growth hormone insensitivity.Reviews in endocrine & metabolic disorders · 2021Review
- Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2020Review
- Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice.Endocrinology · 2020Article
- Tissue-Specific GHR Knockout Mice: An Updated Review.Frontiers in endocrinology · 2020Review
- Crosstalk between the growth hormone/insulin-like growth factor-1 axis and the gut microbiome: A new frontier for microbial endocrinology.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research SocietyReview
- New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice.Archives of endocrinology and metabolismReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveGrowth hormone (GH) has been reported to enhance the intestinal barrier; as such, recombinant GH has been administered for several intestinal diseases. However, excess GH action has been implicated in increasing the risk of intestinal dysfunction. The goal of this study was to examine the direct effects of GH on the small and large intestines to clarify the role GH plays in intestinal function through the use of a mouse model.
designAn intestinal epithelial-specific GH receptor (GHR) knockout (IntGHRKO) mouse line was generated using Cre-lox with the villin promoter driving Cre expression. The generated mice were characterized with respect to growth and intestinal phenotypes.
resultsIntGHRKO mice showed no significant changes in body length, weight, or composition compared to floxed controls. Male IntGHRKO mice had significantly shorter large intestines at 4 and 12 months of age. Intestinal barrier function was assessed by measuring the expression of tight junction related genes, as well as levels of serum endotoxin and fecal albumin. Results showed sex differences as males had an increase in occludin levels but normal serum endotoxin and fecal albumin; while, females had changes in fecal albumin levels with normal occludin and serum endotoxin. Evaluation of glucose tolerance and fat absorption also showed sex differences as females were glucose intolerant, while males had impaired fat absorption. Histopathology revealed a trend towards decreased villus height in males, which could explain the sex difference in glucose homeostasis.
conclusionsOverall, the data demonstrate that disruption of GH on the intestinal epithelial cells modestly affects the intestinal gross anatomy, morphology, and function in a sex-specific manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.