Evidence map›Paper›PMID 31078524›Full record

ReviewExperimental neurology2019

Deferoxamine therapy reduces brain hemin accumulation after intracerebral hemorrhage in piglets.

Shengli Hu, Ya Hua, Richard F Keep, Hua Feng, Guohua Xi

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Efficacy of desferrioxamine mesylate in intracerebral hematoma: a systemic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  2. Review
  3. Receptor-Dependent and -Independent Effects of Hemin on Platelet Plasma Membrane Disintegration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Review
  5. Traumatic brain injury-related ferroptosis: current perspectives.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Involvement of EGFR-AKT signaling in hemin-induced neurotoxicity.Experimental biology and medicine (Maywood, N.J.) · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Shengli HuDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA; Department of Neurosurgery, Southwest Hospital, Chongqing 400038, China.
Ya HuaDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Richard F KeepDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.
Hua FengDepartment of Neurosurgery, Southwest Hospital, Chongqing 400038, China.
Guohua XiDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: guohuaxi@umich.edu.
University of Michigan · USSouthwest Hospital · CN

Funding

Early hematoma lysis and hemoglobin toxicity in intracerebral hemorrhageR01NS106746 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KEEP, RICHARD F · 2018 to 2022
$2.5M
Deferoxamine therapy for intracerebral hemorrhageU01NS052510 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2007 to 2010
$1.8M
Iron, minocycline and brain injury after intracerebral hemorrhageR01NS090925 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2015 to 2019
$1.7M
Targeting CD47 to aid in clearing intracerebral hemorrhagesR01NS096917 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA, XI, GUOHUA · 2016 to 2020
$1.7M
Mechanisms of Brain Injury after Intraventricular HemorrhageR01NS073595 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, GUOHUA · 2012 to 2016
$1.7M
Lipocalin-2 and Intracerebral Hemorrhage-induced Brain InjuryR21NS091545 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUA, YA · 2015 to 2016
$427k
NINDS NIH HHS R01 NS073595NINDS NIH HHS R01 NS090925NINDS NIH HHS R01 NS096917NINDS NIH HHS R01 NS106746NINDS NIH HHS R21 NS091545NINDS NIH HHS U01 NS052510
6 · The paper itself

Abstract

Hemopexin (Hpx) is critical for hemin scavenging after the erythrocyte lysis that occurs following intracerebral hemorrhage (ICH). Low-density lipoprotein receptor-related protein-1 (LRP1, also called CD91) is an important receptor through which the hemin-Hpx complex can undergo endocytosis. This study investigated changes in the hemin-Hpx-CD91 axis in both hematoma and perihematomal tissue in a large animal ICH model. The effect of deferoxamine (DFX) on hemin-Hpx-CD91 was also examined. The study consisted of two parts. First, piglets had an injection of autologous blood into the right frontal lobe of brain and were euthanized from day 1 to day 7. Hematoma and perihematomal tissue of brains were used for hemin assay, immunohistochemistry, and immunofluorescence. Second, piglets with ICH were treated with deferoxamine or vehicle, and were euthanized for hemin measurement and Hpx and CD91 immunohistochemistry. We found that there was an increase of hemin levels within the hematoma and perihematomal brain tissue after ICH. Hpx and CD91-positive cells were present in the clot and perihematomal tissue from day 1. Hpx and CD91 positive cells were Iba1 positive. After DFX therapy, hemin dropped markedly in the hematoma and perihematomal brain tissue. Furthermore, DFX treatment decreased the number of Hpx and CD91 positive cells in and around the hematoma. In conclusion, hemin accumulation occurs in and around the hematoma. Increases in Hpx and CD91 may be important in scavenging that hemin. DFX treatment decreased hemin release from the hematoma and reduced the expression of Hpx and CD91.

Indexed as

AnimalsCerebral HemorrhageDeferoxamineHeminHemopexinLow Density Lipoprotein Receptor-Related Protein-1MaleSiderophoresSwineDeferoxamineHeminHemopexinLow Density Lipoprotein Receptor-Related Protein-1SiderophoresCD91DeferoxamineHeminHemopexinIntracerebral hemorrhageSwine

Identifiers

PMID31078524
PMCPMC6588480
OpenAlexW2944062515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.