Evidence map›Paper›PMID 31078368›Full record

ArticleNeuron2019

Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP.

Takeo Saneyoshi, Hitomi Matsuno, Akio Suzuki, Hideji Murakoshi, Nathan G Hedrick, Emily Agnello, Rory O'Connell, Margaret M Stratton, Ryohei Yasuda, Yasunori Hayashi

Open access · bronzeAbstract read
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 124 citations in OpenAlex.

  1. Pooled it
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  19. Presynaptic Rac1 in the hippocampus selectively regulates working memory.bioRxiv : the preprint server for biology · 2024
    Article
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Takeo SaneyoshiBrain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan. Electronic address: saneyoshi.takeo.3v@kyoto-u.ac.jp.
Hitomi MatsunoBrain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan.
Akio SuzukiBrain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan.
Hideji MurakoshiNational Institute of Physiological Science, Okazaki, Aichi 444-8585, Japan; Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA; Duke University Medical Center, Durham, NC 27703, USA.
Nathan G HedrickMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA; Duke University Medical Center, Durham, NC 27703, USA.
Emily AgnelloDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Rory O'ConnellDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Margaret M StrattonDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Ryohei YasudaMax Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Yasunori HayashiBrain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan; Brain and Body System Science Institute, Saitama University, Saitama 338-8570, Japan; School of Life Science, South China Normal University, Guangzhou 510631, China. Electronic address: yhayashi-tky@umin.ac.jp.
Max Planck Florida Institute for Neuroscience · USUniversity of Massachusetts Amherst · USRIKEN Center for Brain Science · JPKyoto University · JPSouth China Normal University · CN

Funding

Mechanisms of Ras Signaling in Single SynapsesR01MH080047 · NIMH · MAX PLANCK FLORIDA CORPORATION · PI YASUDA, RYOHEI · 2007 to 2023
$6.8M
Deciphering Biochemical Networks in Single Dendritic SpinesDP1NS096787 · NINDS · MAX PLANCK FLORIDA CORPORATION · PI YASUDA, RYOHEI · 2015 to 2019
$4.8M
Optical detection of the molecular processes underlying hippocampal LTPR01DA017310 · NIDA · RIKEN · PI HAYASHI, YASUNORI · 2006 to 2010
$1.3M
NIDA NIH HHS R01 DA017310NIMH NIH HHS R01 MH080047NINDS NIH HHS DP1 NS096787
6 · The paper itself

Abstract

Long-term synaptic plasticity requires a mechanism that converts short Ca

Indexed as

ActinsAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Dendritic SpinesFeedback, PhysiologicalGuanine Nucleotide Exchange FactorsHippocampusLong-Term PotentiationMicroscopy, ConfocalNeuronsPhosphorylationPolymerizationPyronesQuinolinesrac1 GTP-Binding ProteinRatsActinsCalcium-Calmodulin-Dependent Protein Kinase Type 2EHT 1864Guanine Nucleotide Exchange FactorsPyronesQuinolinesrac1 GTP-Binding ProteinRac1 protein, ratTiam1 protein, ratT-Lymphoma Invasion and Metastasis-inducing Protein 1actin cytoskeletonCa(2+)/calmodulin-dependent protein kinase IIdendritic spineguanine-nucleotide exchange factorlong-term potentiationpseudo-autoinhibitory domainreciprocally activating kinase-effector complex (RAKEC)Rho family small GTPasesynaptic plasticity

Identifiers

PMID31078368
PMCPMC6669903
OpenAlexW2944452573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.