ArticleJournal of medical case reports2019
Ciprofloxacin and risk of hypolycemia in non-diabetic patients.
Article in Journal of medical case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Novel Approaching Imidazoles as Insecticidal Agents: Design, Synthesis, Toxicological, Biochemical, and Biological Effectiveness.Chemistry & biodiversity · 2026Article
- Delayed-Onset Hypoglycemia After Levofloxacin Use in a Diabetic Patient.Case reports in medicine · 2025Article
- Ciprofloxacin-Loaded Titanium Nanotubes Coated with Chitosan: A Promising Formulation with Sustained Release and Enhanced Antibacterial Properties.Pharmaceutics · 2022Article
- Insulinotropic Potential ofAntibiotics (Basel, Switzerland) · 2022Article
- Fatal hypoglycemia with ciprofloxacin in a dialysis patient: A case report.Clinical case reports · 2021Article
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4 authors.
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Abstract
backgroundFluoroquinolones have been associated with hypoglycemia in patients taking diabetic medications, most commonly due to drug-drug interactions and other associated risk factors. Except for four published case reports, there are no studies that have found positive associations between ciprofloxacin and hypoglycemia. In all but one of the cases, ciprofloxacin was taken with other hypoglycemic drugs. Recently, the Eritrean National Pharmacovigilance Centre received a serious case of hypoglycemia with recurrent episodes in a young and healthy patient without diabetes following use of oral ciprofloxacin. The aim of the present study is therefore to assess the causal relationship between ciprofloxacin and hypoglycemia in patients without diabetes using the World Health Organization-Uppsala Monitoring Centre global adverse drug reaction database (VigiBase®).
methodsA search was made on the World Health Organization global adverse drug reaction database (August 15, 2018) using "ciprofloxacin" as the drug substance and "hypoglycemia" as the reaction term. Cases that used hypoglycemic drugs (patients with diabetes) concurrently with ciprofloxacin and those with a completeness score below 50% were excluded to control for confounders and to improve the strength of the data. Hill criteria were used to assess causation.
resultsA total of 35 cases of hypoglycemia reported since 1989 from 17 countries in patients without diabetes associated with ciprofloxacin use with a median time to onset of 4 days were retrieved. The cases have a median age of 64 years (interquartile range, 50-85) with a similar male-to-female ratio. Ciprofloxacin was the only suspect and the sole drug administered in 48.5% of the cases. In ten cases, hypoglycemia abated following withdrawal of ciprofloxacin, and reaction recurred in one case on the subsequent rechallenge. Hypoglycemia was marked as "serious" in 20 cases, and the outcome was fatal in two cases.
conclusionsThis assessment found a suggestive causal link between use of ciprofloxacin and hypoglycemia in patients without diabetes.
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