Evidence map›Paper›PMID 31078059›Full record

ArticleTranslational oncology2019

Serum Levels of Hepatocyte Growth Factor and CD40 Ligand Predict Radiation-Induced Liver Injury.

Kyle C Cuneo, Theresa Devasia, Yilun Sun, Matthew J Schipper, David Karnak, Mary A Davis, Dawn Owen, Mary Feng, Issam El Naqa, Latifa Bazzi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  5. The roles of CC chemokines in response to radiation.Radiation oncology (London, England) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Kyle C CuneoDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: kcuneo@umich.edu.
Theresa DevasiaBiostatistics, University of Michigan Medical School, Ann Arbor, MI, USA.
Yilun SunBiostatistics, University of Michigan Medical School, Ann Arbor, MI, USA.
Matthew J SchipperDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA; Biostatistics, University of Michigan Medical School, Ann Arbor, MI, USA.
David KarnakDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Mary A DavisDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Dawn OwenDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Mary FengDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Issam El NaqaDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Latifa BazziDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Randy Ten HakenDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Theodore S LawrenceDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Michael Schuetze · 1988 to 2026
$178.2M
TREATMENT VERIFICATION AND TREATMENT PLAN REFINEMENTP01CA059827 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KESSLER, MARC LEWIS, LAWRENCE, THEODORE S · 1993 to 2018
$37.9M
NCI NIH HHS P01 CA059827NCI NIH HHS P30 CA046592
6 · The paper itself

Abstract

backgroundDeclining liver function is a concerning side effect associated with radiation therapy. Biomarkers of liver toxicity would be useful in personalizing therapy.

methodsAs part of two prospective clinical trials examining adaptive radiation therapy, we collected serum samples from patients receiving liver radiation. We performed a screen of 22 cytokines using a multiplex assay then used ELISA to quantify the cytokines of greatest interest. Subjects were split into screening and validation cohorts. Toxicity was defined as an increase in Child-Pugh score of 2 points or greater within 6 months. Logistic regression models were used to estimate the relationship between our toxicity endpoint and serum cytokine concentrations.

resultsOur initial screen (46 subjects, 11 events) identified hepatocyte growth factor (HGF), CD40L (CD154), and eotaxin (CCL11) as potentially predictive of toxicity. We then tested these markers in an expanded patient cohort (104 subjects, 18 events) with a batch correction due to varying age of the samples which confirmed that high HGF and low CD40L were associated with a subsequent decline in liver function following radiation therapy. Multivariate analysis factoring in baseline Child-Pugh score and mean liver radiation dose demonstrated that HGF and CD40L were potentially predictive of toxicity (HGF OR 4.3, P = .009; CD40L OR 0.5 P = .06). Additionally, higher than median baseline HGF levels (1.4 ng/ml) were significantly associated with decreased survival following liver radiation (27.1 vs 14.5 months, P = .03).

conclusionsOur study identifies high HGF and low CD40L as potential markers of liver toxicity following radiation therapy.

Identifiers

PMID31078059
PMCPMC6514276
OpenAlexW2944579490

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.