ArticleNeuroImage. Clinical2019
Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC).
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05783934 (Evaluation of the Degree of Demyelination and Remyelination in Multiple Sclerosis), which is not on this map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Degree of Demyelination and Remyelination in Multiple Sclerosis (MS) Detected by Brain Positron Emission Tomography With Amyloid Markers (PET-CT 18F-Florbetaben) and Comparison With MRI Findings
Who cites it
14 citing papers in PubMed.
- Concordance Between Amyloid-PET Quantification and Real-World Visual Reads.JAMA neurology · 2025Article
- Novel β-amyloid PET Imaging Study of [ACS omega · 2024Article
- New horizons in the diagnosis and management of Alzheimer's Disease in older adults.Age and ageing · 2024Review
- Feasibility evaluation of middle-phaseQuantitative imaging in medicine and surgery · 2023Article
- A multicenter evaluation of a deep learning software (LungQuant) for lung parenchyma characterization in COVID-19 pneumonia.European radiology experimental · 2023Article
- A comparison of advanced semi-quantitative amyloid PET analysis methods.European journal of nuclear medicine and molecular imaging · 2022Article
- Quantification of amyloid PET for future clinical use: a state-of-the-art review.European journal of nuclear medicine and molecular imaging · 2022Review
- Evaluation of semi-quantitative measures ofQuantitative imaging in medicine and surgery · 2022Article
- The approval of a disease-modifying treatment for Alzheimer's disease: impact and consequences for the nuclear medicine community.European journal of nuclear medicine and molecular imaging · 2021Article
- A multisite analysis of the concordance between visual image interpretation and quantitative analysis of [European journal of nuclear medicine and molecular imaging · 2021Article
- PET amyloid in normal aging: direct comparison of visual and automatic processing methods.Scientific reports · 2020Article
- A kinetics-based approach to amyloid PET semi-quantification.European journal of nuclear medicine and molecular imaging · 2020Article
- No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven-year follow-up study.BMC neurology · 2020Article
- Evaluation of a visual interpretation method for tau-PET withAlzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
Corrections and comments
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Authors and funding
26 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundamyloid-PET reading has been classically implemented as a binary assessment, although the clinical experience has shown that the number of borderline cases is non negligible not only in epidemiological studies of asymptomatic subjects but also in naturalistic groups of symptomatic patients attending memory clinics. In this work we develop a model to compare and integrate visual reading with two independent semi-quantification methods in order to obtain a tracer-independent multi-parametric evaluation.
methodsWe retrospectively enrolled three cohorts of cognitively impaired patients submitted to
conclusionIt is possible to construct a map between different tracers and different quantification methods without resorting to ad-hoc acquired cases. We used a 5-level visual scale which, together with a mathematical model, delivered cut-offs and transition regions on tracers that are (largely) independent from the population. All fluorinated tracers appeared to have the same contrast and discrimination ability with respect to the negative-to-positive grading. We validated the integration of both visual reading and different quantifiers in a more robust framework thus bridging the gap between a binary and a user-independent continuous scale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.