ArticleNeuroImage. Clinical2019
Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain.
Open access · goldAbstract read
In one paragraph
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 3 pooled it
8.7field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Systematic review: fluid biomarkers and machine learning methods to improve the diagnosis from mild cognitive impairment to Alzheimer's disease.Alzheimer's research & therapy · 2023Pooled it
- Task-Free Functional Language Networks: Reproducibility and Clinical Application.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Pooled it
- A Systematic Review of the Association between Amyloid-β and τ Pathology with Functional Connectivity Alterations in the Alzheimer Dementia Spectrum Utilizing PET Scan and rsfMRI.Dementia and geriatric cognitive disorders extraPooled it
- Group-level versus individualized approaches for capturing tau PET changes and clinical progression in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer's disease.Research square · 2026Article
- Contribution of local amyloid-β and tau burden to hypometabolism in autosomal-dominant Alzheimer's disease.Brain communications · 2026Article
- Distinct patterns of spontaneous brain activity in mild cognitive impairment patients stratified by cerebrospinal fluid biomarkers.Frontiers in aging neuroscience · 2026Article
- Functional network contributions to longitudinal tau spread in Posterior Cortical Atrophy.NPJ dementia · 2026Article
- Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease.Brain : a journal of neurology · 2025Article
- Patient-specific functional brain architecture explains cortical patterns of tau PET in Alzheimer's disease.bioRxiv : the preprint server for biology · 2025Article
- Patterns of pathological tau deposition reflect the dynamics of cortical brain activity.Cell reports · 2025Article
- Object fine-grained discrimination as a sensitive cognitive marker of transentorhinal integrity.Communications biology · 2025Article
- Whole-brain functional connectivity predicts regional tau PET in preclinical Alzheimer's disease.Brain communications · 2025Article
- Sex-specific topological structure associated with dementia via latent space estimation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Association of Seizure Foci and Location of Tau and Amyloid Deposition and Brain Atrophy in Patients With Alzheimer Disease and Seizures.Neurology · 2024Article
- Human Alzheimer's Disease ATN/ABC Staging Applied to Aging Rhesus Macaque Brains: Association With Cognition and MRI-Based Regional Gray Matter Volume.The Journal of comparative neurology · 2024Article
- Evaluating the Effect of Alzheimer's Disease-Related Biomarker Change in Corticobasal Syndrome and Progressive Supranuclear Palsy.Annals of neurology · 2024Article
- Functional connectivity changes in neurodegenerative biomarker-positive athletes with repeated concussions.Journal of neurology · 2024Article
- The spatial distribution of coupling between tau and neurodegeneration in amyloid-β positive mild cognitive impairment.Neurobiology of aging · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 2 countries.
Rik OssenkoppeleMemory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA; Department of Neurology & Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam 1081 HZ, the Netherlands. Electronic address: r.ossenkoppele@vumc.nl.
Leonardo IaccarinoMemory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA.
Daniel R SchonhautMemory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA.
Jesse A BrownMemory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA.
Renaud La JoieMemory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA.
James P O'NeilMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Mustafa JanabiMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Suzanne L BakerMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Joel H KramerMemory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA.
Maria-Luisa Gorno-TempiniMemory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA.
Bruce L MillerMemory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA.
Howard J RosenMemory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA.
William W SeeleyMemory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA.
William J JagustHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Gil D RabinoviciMemory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA.
University of California, San Francisco · USLawrence Berkeley National Laboratory · US
Funding
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Serggio Carlo Lanata · 2019 to 2026
$36.9MPrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1MNeural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0MProgressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0MConnectomic imaging in familial and sporadic frontotemporal degenerationU01AG052943 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GORNO TEMPINI, MARIA LUISA, GROSSMAN, MURRAY · 2016 to 2019
$5.9MDynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6MEarly Age-of-Onset AD: Clinical Heterogeneity and Network DegenerationR01AG045611 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RABINOVICI, GIL DAN · 2014 to 2018
$3.1MTraining program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9MPatient-tailored network prediction of neurodegenerative disease progressionK01AG055698 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BROWN, JESSE AARON · 2017 to 2022
$779kPrimary Progessive Aphasia: Cognition, Anatomy and ProgressionR56NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2008 to 2008
$315kNIA NIH HHS K01 AG055698NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG034570NIA NIH HHS R01 AG045611NIA NIH HHS U01 AG052943NIDCD NIH HHS K24 DC015544NINDS NIH HHS R01 NS050915NINDS NIH HHS R01 NS100440NINDS NIH HHS R56 NS050915
Abstract
According to the network model of neurodegeneration, the spread of pathogenic proteins occurs selectively along connected brain regions. We tested in vivo whether the distribution of filamentous tau (measured with [
Indexed as
Magnetic Resonance ImagingPositron-Emission Tomographytau ProteinsAdolescentAgedAlzheimer DiseaseBrainCross-Sectional StudiesFemaleHumansMaleMiddle AgedNerve NetYoung AdultMAPT protein, humantau ProteinsAlzheimer's diseaseAmyloidFlortaucipirFunctional connectivityPETTau
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.