ArticleNeuroImage. Clinical2019
The impact of white matter hyperintensities on the structural connectome in late-life depression: Relationship to executive functions.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01728194 (White Matter and Emotional and Cognitive Control in Late-Onset Depression), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
White Matter and Emotional and Cognitive Control in Late-Onset Depression
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- The association between white matter hyperintensities and suicide attempts in affective disorders: a systematic review and meta-analysis.Translational psychiatry · 2025Pooled it
- Gray matter and cognitive alteration related to chronic obstructive pulmonary disease patients: combining ALE meta-analysis and MACM analysis.Brain imaging and behavior · 2025Pooled it
- Early effect of thrombolysis on structural brain network organisation after anterior-circulation stroke in the randomized WAKE-UP trial.Human brain mapping · 2022Trial
- Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke.Nature communications · 2021Trial
- Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020Trial
- Depression as an early symptom and risk factor of dementia - a narrative review.Frontiers in psychiatry · 2026Review
- Complex Neurobiological Mechanisms and Risk Factors Underlying Late-Life Depression.Advances in experimental medicine and biology · 2026Review
- The mediating role of instrumental activities of daily living between cognitive function and depressive symptoms in community-dwelling older adults: the Arao study.BMC psychiatry · 2025Article
- Altered triple network model connectivity is associated with cognitive function and depressive symptoms in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Structural Disconnections Caused by White Matter Hyperintensities in Post-Stroke Spatial Neglect.Human brain mapping · 2024Article
- The relationship between cortical thickness and white matter hyperintensities in mid to late life.Neurobiology of aging · 2024Article
- Classification of MDD using a Transformer classifier with large-scale multisite resting-state fMRI data.Human brain mapping · 2024Article
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder.Therapeutic advances in psychopharmacology · 2024Review
- Body Mass Index, White Matter Hyperintensities, and Cognitive Performance in American Indians: Data from the Strong Heart Study.Journal of racial and ethnic health disparities · 2023Article
- The heterogeneity of late-life depression and its pathobiology: a brain network dysfunction disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Gray matter volume and within-task verbal fluency performance among older adults.Brain and cognition · 2023Article
- Automatic diagnosis of late-life depression by 3D convolutional neural networks and cross-sample Entropy analysis from resting-state fMRI.Brain imaging and behavior · 2023Article
- Effects of white matter hyperintensities on isolated executive function assessed by the Trail Making Test.F1000Research · 2023Article
- The enigma of vascular depression in old age: a critical update.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWhite matter hyperintensities (WMH) represent ischemic white matter damage in late-life depression (LLD) and are associated with cognitive control dysfunction. Understanding the impact of WMH on the structural connectivity of gray matter and the cognitive control correlates of WMH-related structural dysconnectivity can provide insight into the pathophysiology of LLD.
methodsWe compared WMH burden and performance on clinical measures of cognitive control in patients with LLD (N = 44) and a control group of non-depressed older adults (N = 59). We used the Network Modification (NeMo) Tool to investigate the impact of WMH on structural dysconnectivity in specific gray matter regions, and how such connectivity was related to cognitive control functions.
resultsCompared to the control group, LLD participants had greater WMH burden, poorer performance on Trail Making Test (TMT) A & B, and greater self-reported dysexecutive behavior on the Frosntal Systems Behavior Scale-Executive Function subscale (FrSBe-EF). Within the LLD group, disrupted connectivity in the left supramarginal gyrus, paracentral lobule, thalamus, and pallidum was associated with psychomotor slowing (TMT-A). Altered connectivity in the left supramarginal gyrus, paracentral lobule, precentral gyrus, postcentral gyrus, thalamus, and pallidum was associated with poor attentional set-shifting (TMT-B). A follow-up analysis that isolated set-shifting ability (TMT-B/A ratio) confirmed the association with dysconnectivity in the bilateral paracentral lobule, right thalamus, left precentral gyrus, postcentral gyrus, and pallidum; additionally, it revealed associations with dysconnectivity in the right posterior cingulate, and left anterior cingulate, middle frontal cortex, and putamen.
conclusionsIn LLD, WMH are associated with region-specific disruptions in cortical and subcortical gray matter areas involved in attentional aspects of cognitive control systems and sensorimotor processing, which in turn are associated with slower processing speed, and reduced attentional set-shifting. CLINICAL TRIALS REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT01728194.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.