ArticleNeuroImage. Clinical2019
Linked anatomical and functional brain alterations in children with attention-deficit/hyperactivity disorder.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- White matter alterations in Attention-Deficit/Hyperactivity Disorder (ADHD): a systematic review of 129 diffusion imaging studies with meta-analysis.Molecular psychiatry · 2023Pooled it
- Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis.Human brain mapping · 2020Trial
- From heterogeneity to translation: data‑driven subtyping of autism in a multilevel framework.Translational psychiatry · 2026Review
- Neural mechanisms of guided internet-based cognitive behavioral therapy for children with attention-deficit/hyperactivity disorder: a protocol for a prospective multimodal MRI study.Frontiers in psychiatry · 2026Article
- Brain structure characteristics in children with attention-deficit/hyperactivity disorder elucidated using traveling-subject harmonization.Molecular psychiatry · 2025Article
- Clinically Relevant Patterns of Co-Fluctuating Structure and Function in Multiple Sclerosis.European journal of neurology · 2025Article
- The Multidimensional Dynamic Feedback Model: A Comprehensive Framework for Understanding and Managing Attention-Deficit/Hyperactivity Disorder.Children (Basel, Switzerland) · 2025Review
- Frequencies and patterns of symptoms in Chinese adults with accommodative and binocular dysfunctions.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Article
- Shared grey matter correlates of reading and attention.Brain and language · 2023Article
- Data-driven multimodal fusion: approaches and applications in psychiatric research.Psychoradiology · 2023Review
- The potential involvement of inhaled iron (Fe) in the neurotoxic effects of ultrafine particulate matter air pollution exposure on brain development in mice.Particle and fibre toxicology · 2022Article
- Article
- Gray matter volumetric correlates of attention deficit and hyperactivity traits in emerging adolescents.Scientific reports · 2022Article
- Neuroprotection in late life attention-deficit/hyperactivity disorder: A review of pharmacotherapy and phenotype across the lifespan.Frontiers in human neuroscience · 2022Review
- Uncovering Statistical Links Between Gene Expression and Structural Connectivity Patterns in the Mouse Brain.Neuroinformatics · 2021Article
- Resting-State Functional Connectivity and Psychopathology in Klinefelter Syndrome (47, XXY).Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Advances in functional and diffusion neuroimaging research into the long-term consequences of very preterm birth.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Structural brain network topology underpinning ADHD and response to methylphenidate treatment.Translational psychiatry · 2021Article
- Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan.NeuroImage. Clinical · 2020Article
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Authors and funding
15 authors.
Funding
Abstract
objectivesNeuroimaging studies have independently demonstrated brain anatomical and functional impairments in participants with ADHD. The aim of the current study was to explore the relationship between structural and functional brain alterations in ADHD through an integrated analysis of multimodal neuroimaging data.
methodsWe performed a multimodal analysis to integrate resting-state functional magnetic resonance imaging (MRI), structural MRI, and diffusion-weighted imaging data in a large, single-site sample of children with and without diagnosis for ADHD. The inferred subject contributions were fed into regression models to investigate the relationships between diagnosis, symptom severity, gender, and age.
resultsCompared with controls, children with ADHD diagnosis showed altered white matter microstructure in widespread white matter fiber tracts as well as greater gray matter volume (GMV) in bilateral frontal regions, smaller GMV in posterior regions, and altered functional connectivity (FC) in default mode and fronto-parietal networks. Age-related growth of GMV of bilateral occipital lobe, FC in frontal regions as well as age-related decline of GMV in medial regions seen in controls appeared reversed in children with ADHD. In the whole group, higher symptom severity was related to smaller GMV in widespread regions in bilateral frontal, parietal, and temporal lobes, as well as greater GMV in intracalcarine and temporal cortices.
conclusionsThrough a multimodal analysis approach we show that structural and functional alterations in brain regions known to be altered in subjects with ADHD from unimodal studies are linked across modalities. The brain alterations were related to clinical features of ADHD, including disorder status, age, and symptom severity.
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