ArticleAquatic toxicology (Amsterdam, Netherlands)2019
Xenobiotic transporter activity in zebrafish embryo ionocytes.
Article in Aquatic toxicology (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Article
- Progress in characterizing ABC multidrug transporters in zebrafish.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2024Article
- Transcriptome and Proteome Analyses Reveal Stage-Specific DNA Damage Response in Embryos of Sturgeon (International journal of molecular sciences · 2022Article
- Zebrafish (American journal of physiology. Renal physiology · 2022Article
- Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter.Scientific reports · 2021Article
- Interactions of Environmental Chemicals and Natural Products With ABC and SLC Transporters in the Digestive System of Aquatic Organisms.Frontiers in physiology · 2021Article
- Expression and Function of ABC Proteins in Fish Intestine.Frontiers in physiology · 2021Review
- Disruption of small molecule transporter systems by Transporter-Interfering Chemicals (TICs).FEBS letters · 2020Review
- Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal models.F1000Research · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Ionocytes are specialized cells in the epidermis of embryonic zebrafish (Danio rerio) that play important roles in ion homeostasis and have functional similarities to mammalian renal cells. Here, we examined whether these cells might also share another functional similarity with renal cells, which is the presence of efflux transporter activities useful for elimination of toxic small molecules. Xenobiotic transporters (XTs), including the ATP-Binding Cassette (ABC) family, are a major defense mechanism against diffusible toxic molecules in aquatic embryos, including zebrafish, but their activity in the ionocytes has not previously been studied. Using fluorescent small molecule substrates of XT, we observed that specific populations of ionocytes uptake and efflux fluorescent small molecules in a manner consistent with active transport. We specifically identified a P-gp/ABCB1 inhibitor-sensitive efflux activity in the H
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