ArticleTransboundary and emerging diseases2019
Prevalence of a novel bovine coronavirus strain with a recombinant hemagglutinin/esterase gene in dairy calves in China.
Article in Transboundary and emerging diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- A Review: Bovine Coronavirus Evolution, Molecular Epidemiology, and Genetic Variation.Viruses · 2026Review
- Genetic diversity of bovine coronaviruses from recurrent outbreaks on a large-scale cattle farm.Tropical animal health and production · 2026Article
- A survey of bovine coronavirus infections in cattle with respiratory disease in Chiba Prefecture, Japan.The Journal of veterinary medical science · 2026Article
- Identification and characterization of new B cell epitopes on the nucleocapsid protein of bovine coronavirus using monoclonal antibodies.Frontiers in cellular and infection microbiology · 2026Article
- Large-scale characterization of the bovine virome reveals viral diversity and community patterns in Northwest China.Frontiers in microbiology · 2026Article
- Farm animal coronaviruses: the solution is in vaccines.The veterinary quarterly · 2025Review
- Diagnostic Methods for Bovine Coronavirus: A Review of Recent Advancements and Challenges.Viruses · 2025Review
- Seroprevalence of coronaviruses of cattle and pigs in Belgian herds.BMC veterinary research · 2025Article
- Prevalence and genetic characterization of diarrhea viruses among cattle in Guangdong, China.BMC veterinary research · 2025Article
- Isolation and characterization of bovine coronavirus variants with mutations in the hemagglutinin-esterase gene in dairy calves in China.BMC veterinary research · 2025Article
- Molecular detection of coronavirus in camelids and bovines using real-time quantitative polymerase chain reaction in Wasit Province, Iraq.Open veterinary journal · 2025Article
- Prevalence and Evolutionary Characteristics of Bovine Coronavirus in China.Veterinary sciences · 2024Article
- Genetic characterization of bovine coronavirus strain isolated in Inner Mongolia of China.BMC veterinary research · 2024Article
- Development of Rapid Isothermal Detection Methods Real-Time Fluorescence and Lateral Flow Reverse Transcription Recombinase-Aided Amplification Assay for Bovine Coronavirus.Transboundary and emerging diseases · 2024Article
- Screening of Bovine Coronavirus Multiepitope Vaccine Candidates: An Immunoinformatics Approach.Transboundary and emerging diseases · 2024Article
- Establishment and application of multiplex droplet digital polymerase chain reaction assay for bovine enterovirus, bovine coronavirus, and bovine rotavirus.Frontiers in veterinary science · 2023Article
- Article
- Advances in Bovine Coronavirus Epidemiology.Viruses · 2022Review
- Infectivity and Morphology of Bovine Coronavirus Inactivated In Vitro by Cationic Photosensitizers.Viruses · 2022Article
- Development and use of a reverse transcription insulated isothermal PCR assay for detection and characterization of bovine torovirus in yaks.Archives of virology · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Bovine coronavirus (BCoV) is the causative agent of diarrhoea in newborn calves, winter dysentery in adult cattle and respiratory tract illnesses in cattle across the world. In this study, a total of 190 faecal samples from dairy calves with diarrhoea were collected from 14 farms in six Chinese provinces, and BCoV was detected in 18.95% (36/190) of the samples by reverse transcriptase polymerase chain reaction. Full-length spike, hemagglutinin/esterase (HE), nucleocapsid and transmembrane genes were simultaneously cloned from 13 clinical samples (eight farms in four provinces), and most of the BCoV strains showed a unique evolutionary pattern based on the phylogenetic analysis of these genes. Interesting, 10 of the 13 strains were identified as HE recombinant strains, and these strains had experienced the same recombination event and carried the same recombination sites located between the esterase and lectin domain. They also shared an identical aa variant (F181V) in the R2-loop. Moreover, 9/10 strains displayed another identical aa variant (P, S158A) in the adjacent R1-loop of the HE gene, which differs from the other available BCoV HE sequences in the GenBank database. Our results showed that BCoV is widely circulating in dairy cattle in China, contributing to the diagnosis and control of dairy calves diarrhoea. Furthermore, a BCoV strain that carries a recombinant HE gene has spread in dairy calves in China. To the best of our knowledge, this is the first description of an HE recombination event occurring in BCoV; this is also the first description of the molecular prevalence of BCoV in China. Our findings will enhance current understanding about the genetic evolution of BCoV.
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