ArticlePsychiatry and clinical neurosciences2019
Shared preventive factors associated with relapse after a response to electroconvulsive therapy in four major psychiatric disorders.
Article in Psychiatry and clinical neurosciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Relapse Following Electroconvulsive Therapy for Schizophrenia: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2026Pooled it
- Maintenance pharmacotherapy after electroconvulsive therapy in inpatients with major depressive disorder: 198 prescriptions in a real-world clinical setting.BMC psychiatry · 2025Article
- Clinical and sociodemographic characteristics associated with relapse following electroconvulsive therapy for bipolar disorder.Bipolar disorders · 2024Article
- Trajectories of Efficacy and Cognitive Function During Electroconvulsive Therapy Course in Young Adults with Treatment-Resistant Depression.Neuropsychiatric disease and treatment · 2023Article
- Major depressive disorder: Validated treatments and future challenges.World journal of clinical cases · 2021Review
- Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study.Journal of personalized medicine · 2021Article
- Effects of Electroconvulsive Therapy on Depression and Its Potential Mechanism.Frontiers in psychology · 2020Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe efficacy of electroconvulsive therapy (ECT) has been established in psychiatric disorders but the high rate of relapse is a critical problem. The current study sought preventative factors associated with relapse after a response to ECT in a continuum of four major psychiatric disorders.
methodsThe records of 255 patients with four psychiatric disorders (83 unipolar depression, 60 bipolar depression, 91 schizophrenia, 21 schizoaffective disorder) were retrospectively reviewed.
resultsThe relapse-free rate of all patients at 1 year was 56.3% in the four psychiatric disorders without a difference. As a result of univariate analysis, three items could be considered as preventative factors associated with relapse: a small number of psychiatric symptom episodes before an acute course of ECT, the use of mood stabilizers, and the use of maintenance ECT. Multivariate analysis was performed, keeping age, sex, and diagnosis constant in addition to the three items, and small number of psychiatric symptom episodes before an acute course of ECT (P = 0.003), the use of lithium (P = 0.025), the use of valproate (P = 0.027), and the use of maintenance ECT (P = 0.001) were found to be significant preventative measures against relapse.
conclusionThe use of mood stabilizers, such as lithium and valproate, and maintenance ECT could be shared preventive factors associated with relapse after a response to ECT in four major psychiatric disorders.
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