Evidence map›Paper›PMID 31077356›Full record

ArticleInternational journal of cancer2019

Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist

Bogdan Mitran, Sara S Rinne, Mark W Konijnenberg, Theodosia Maina, Berthold A Nock, Mohamed Altai, Anzhelika Vorobyeva, Mats Larhed, Vladimir Tolmachev, Marion de Jong and 2 more

Open access · hybridAbstract read
In one paragraph

Article in International journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Antitumor efficacy and safety of locoregional [European journal of nuclear medicine and molecular imaging · 2026
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  3. Comparative Study of NOTA-Derived Chelators: Synthesis, AlInternational journal of molecular sciences · 2026
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  4. Rhenium-186-labeledRSC advances · 2026
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  6. RM2 and DB15 analogues bearing [EJNMMI radiopharmacy and chemistry · 2025
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  7. Article
  8. Article
  9. Preclinical Investigation of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Co-injection of anti-HER2 antibody Trastuzumab does not increase efficacy of [American journal of nuclear medicine and molecular imaging · 2023
    Article
  17. Frontiers in oncology · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Bogdan MitranDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Sara S RinneDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Mark W KonijnenbergDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Theodosia MainaMolecular Radiopharmacy, INRASTES, NCSR "Demokritos", Athens, Greece.
Berthold A NockMolecular Radiopharmacy, INRASTES, NCSR "Demokritos", Athens, Greece.
Mohamed AltaiDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Anzhelika VorobyevaDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Mats LarhedDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Vladimir TolmachevDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Marion de JongDepartment of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Ulrika RosenströmDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Anna OrlovaDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.ORCID 0000-0001-6120-2683
Uppsala University · SEErasmus MC · NLNational Centre of Scientific Research "Demokritos" · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrin-releasing peptide receptors (GRPRs) are overexpressed in prostate cancer and are suitable for targeted radionuclide therapy (TRT). We optimized the bombesin-derived GRPR-antagonist PEG

Indexed as

AnimalsAntineoplastic AgentsCell Line, TumorCombined Modality TherapyHeterograftsHumansLutetiumMaleMiceMice, Inbred BALB CMice, NudePC-3 CellsPolyethylene GlycolsProstateProstatic NeoplasmsRadioisotopesAntineoplastic AgentsLutetiumLutetium-177Polyethylene GlycolsRadioisotopesReceptors, BombesinTpt1 protein, mouseTrastuzumabTumor Protein, Translationally-Controlled 1GRPRHER2lutetium-177prostate cancerradionuclide therapy

Identifiers

PMID31077356
PMCPMC6852655
OpenAlexW2944699890

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.