ArticleMolecular biology and evolution2019
Human Migration and the Spread of the Nematode Parasite Wuchereria bancrofti.
Article in Molecular biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
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- Calibrating and documenting host-switching and evolution of incompatibility loci for two closely relatedbioRxiv : the preprint server for biology · 2026Article
- Population genomics reveals an ancient origin of heartworms in canids.Communications biology · 2026Article
- Ghosts of symbionts past: the hidden history of the dynamic association between filarial nematodes and their Wolbachia endosymbionts.G3 (Bethesda, Md.) · 2025Article
- Beyond business as usual for lymphatic filariasis mass drug administration in hotspot districts.International health · 2025Article
- Enrichment of Helminth Mitochondrial Genomes From Faecal Samples Using Hybridisation Capture.Molecular ecology resources · 2025Article
- Strong Bottlenecks Constrain Adaptive Coevolution in a Host-Parasite Metapopulation.Molecular ecology · 2025Article
- Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets.Nature communications · 2025Article
- Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta.PLoS pathogens · 2025Article
- Turning the needle into the haystack: Culture-independent amplification of complex microbial genomes directly from their native environment.PLoS pathogens · 2024Review
- Evaluating evidence for co-geography in the Anopheles-Plasmodium host-parasite system.G3 (Bethesda, Md.) · 2024Article
- The African mosquito-borne diseasosome: geographical patterns, range expansion and future disease emergence.Proceedings. Biological sciences · 2023Article
- Evaluating evidence for co-geography in thebioRxiv : the preprint server for biology · 2023Article
- Population Genomic Evidence of Adaptive Response during the Invasion History of Plasmodium falciparum in the Americas.Molecular biology and evolution · 2023Article
- A fast machine-learning-guided primer design pipeline for selective whole genome amplification.PLoS computational biology · 2023Article
- ElucidatingFrontiers in parasitology · 2023Article
- Population genomics of ancient and modern Trichuris trichiura.Nature communications · 2022Article
- Characterization of a novel microfilarial antigen for diagnosis of Wuchereria bancrofti infections.PLoS neglected tropical diseases · 2022Article
- Genomic analysis of a parasite invasion: Colonization of the Americas by the blood fluke Schistosoma mansoni.Molecular ecology · 2022Article
- Distinct N-Linked Immunoglobulin G Glycosylation Patterns Are Associated With Chronic Pathology and Asymptomatic Infections in Human Lymphatic Filariasis.Frontiers in immunology · 2022Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The human disease lymphatic filariasis causes the debilitating effects of elephantiasis and hydrocele. Lymphatic filariasis currently affects the lives of 90 million people in 52 countries. There are three nematodes that cause lymphatic filariasis, Brugia malayi, Brugia timori, and Wuchereria bancrofti, but 90% of all cases of lymphatic filariasis are caused solely by W. bancrofti (Wb). Here we use population genomics to reconstruct the probable route and timing of migration of Wb strains that currently infect Africa, Haiti, and Papua New Guinea (PNG). We used selective whole genome amplification to sequence 42 whole genomes of single Wb worms from populations in Haiti, Mali, Kenya, and PNG. Our results are consistent with a hypothesis of an Island Southeast Asia or East Asian origin of Wb. Our demographic models support divergence times that correlate with the migration of human populations. We hypothesize that PNG was infected at two separate times, first by the Melanesians and later by the migrating Austronesians. The migrating Austronesians also likely introduced Wb to Madagascar where later migrations spread it to continental Africa. From Africa, Wb spread to the New World during the transatlantic slave trade. Genome scans identified 17 genes that were highly differentiated among Wb populations. Among these are genes associated with human immune suppression, insecticide sensitivity, and proposed drug targets. Identifying the distribution of genetic diversity in Wb populations and selection forces acting on the genome will build a foundation to test future hypotheses and help predict response to current eradication efforts.
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