ArticleJournal of the American Medical Informatics Association : JAMIA2019
A novel approach for exposing and sharing clinical data: the Translator Integrated Clinical and Environmental Exposures Service.
Article in Journal of the American Medical Informatics Association : JAMIA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Causal analysis for multivariate integrated clinical and environmental exposures data.BMC medical informatics and decision making · 2025Article
- FHIR PIT: a geospatial and spatiotemporal data integration pipeline to support subject-level clinical research.BMC medical informatics and decision making · 2025Article
- Generating Biomedical Knowledge Graphs from Knowledge Bases, Registries, and Multiomic Data.bioRxiv : the preprint server for biology · 2024Article
- Enriching Real-world Data with Social Determinants of Health for Health Outcomes and Health Equity: Successes, Challenges, and Opportunities.Yearbook of medical informatics · 2023Article
- ARAX: a graph-based modular reasoning tool for translational biomedicine.Bioinformatics (Oxford, England) · 2023Article
- The Exposome and Nutritional Pharmacology and Toxicology: A New Application for Metabolomics.Exposome · 2023Article
- Long-term exposure to particulate matter was associated with increased dementia risk using both traditional approaches and novel machine learning methods.Scientific reports · 2022Article
- Development and Application of an Open Tool for Sharing and Analyzing Integrated Clinical and Environmental Exposures Data: Asthma Use Case.JMIR formative research · 2022Article
- Leveraging Open Electronic Health Record Data and Environmental Exposures Data to Derive Insights Into Rare Pulmonary Disease.Frontiers in artificial intelligence · 2022Article
- Open Application of Statistical and Machine Learning Models to Explore the Impact of Environmental Exposures on Health and Disease: An Asthma Use Case.International journal of environmental research and public health · 2021Article
- An approach for open multivariate analysis of integrated clinical and environmental exposures data.Informatics in medicine unlocked · 2021Article
- Visualization Environment for Federated Knowledge Graphs: Development of an Interactive Biomedical Query Language and Web Application Interface.JMIR medical informatics · 2020Article
- Translator Exposure APIs: Open Access to Data on Airborne Pollutant Exposures, Roadway Exposures, and Socio-Environmental Exposures and Use Case Application.International journal of environmental research and public health · 2020Article
- FHIR PIT: an open software application for spatiotemporal integration of clinical data and environmental exposures data.BMC medical informatics and decision making · 2020Article
- Sex, obesity, diabetes, and exposure to particulate matter among patients with severe asthma: Scientific insights from a comparative analysis of open clinical data sources during a five-day hackathon.Journal of biomedical informatics · 2019Article
- Fast Healthcare Interoperability Resources (FHIR) as a Meta Model to Integrate Common Data Models: Development of a Tool and Quantitative Validation Study.JMIR medical informatics · 2019Article
- Clinical Data: Sources and Types, Regulatory Constraints, Applications.Clinical and translational science · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveThis study aimed to develop a novel, regulatory-compliant approach for openly exposing integrated clinical and environmental exposures data: the Integrated Clinical and Environmental Exposures Service (ICEES). MATERIALS AND
methodsThe driving clinical use case for research and development of ICEES was asthma, which is a common disease influenced by hundreds of genes and a plethora of environmental exposures, including exposures to airborne pollutants. We developed a pipeline for integrating clinical data on patients with asthma-like conditions with data on environmental exposures derived from multiple public data sources. The data were integrated at the patient and visit level and used to create de-identified, binned, "integrated feature tables," which were then placed behind an OpenAPI.
resultsOur preliminary evaluation results demonstrate a relationship between exposure to high levels of particulate matter ≤2.5 µm in diameter (PM2.5) and the frequency of emergency department or inpatient visits for respiratory issues. For example, 16.73% of patients with average daily exposure to PM2.5 >9.62 µg/m3 experienced 2 or more emergency department or inpatient visits for respiratory issues in year 2010 compared with 7.93% of patients with lower exposures (n = 23 093). DISCUSSION: The results validated our overall approach for openly exposing and sharing integrated clinical and environmental exposures data. We plan to iteratively refine and expand ICEES by including additional years of data, feature variables, and disease cohorts.
conclusionsWe believe that ICEES will serve as a regulatory-compliant model and approach for promoting open access to and sharing of integrated clinical and environmental exposures data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.