ArticleLipids in health and disease2019
Lipidomics coupled with pathway analysis characterizes serum metabolic changes in response to potassium oxonate induced hyperuricemic rats.
Article in Lipids in health and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Herbal medicine,Frontiers in pharmacology · 2023Pooled it
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- Ameliorating Acute Kidney Injury Induced by Ischemia-Reperfusion by Targeting Purine Metabolism.International journal of molecular sciences · 2025Article
- Hyperuricemia Is Independently Associated With Hyperlipidemia in a Large Population-Based Study.Journal of clinical laboratory analysis · 2025Article
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- UHPLC-MS/MS-based plasma untargeted lipidomic analysis in patients with diabetes mellitus combined with hyperuricemia.Frontiers in molecular biosciences · 2025Article
- Dietary carbohydrate to lipid ratio affects growth, reproductive performance and health of female yellow catfish (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Associations of Plasma Lipidomic Profiles with Uric Acid and Hyperuricemia Risk in Middle-Aged and Elderly Chinese.Phenomics (Cham, Switzerland) · 2024Article
- Mendelian randomization analysis identified potential genes pleiotropically associated with gout.Frontiers in genetics · 2024Article
- Article
- Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment.Arthritis research & therapy · 2023Article
- The Underling Mechanisms Exploration ofDrug design, development and therapy · 2023Article
- Early weaning leads to the remodeling of lipid profile in piglet jejunal crypt cells during post-weaning days.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Investigation of pathogenesis of hyperuricemia based on untargeted and targeted metabolomics.Scientific reports · 2022Article
- Investigation of pathogenesis of hyperuricemia based on untargeted and targeted metabolomics.Scientific reports · 2022Article
- Lipidomic analysis reveals disturbances in glycerophospholipid and sphingolipid metabolic pathways in benzene-exposed mice.Toxicology research · 2021Article
- Lipidomics study of the therapeutic mechanism of Plantaginis Semen in potassium oxonate-induced hyperuricemia rat.BMC complementary medicine and therapies · 2021Article
- High-Throughput Untargeted Serum Metabolomics Analysis of Hyperuricemia Patients by UPLC-Q-TOF/MS.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Exploring the Typicality, Sensory Space, and Chemical Composition of Swedish Solaris Wines.Foods (Basel, Switzerland) · 2020Article
- NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats.Oxidative medicine and cellular longevity · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperuricemia as a metabolic disease is usually associated with lipid metabolic disorder. The purpose of this study is to identify potential lipid biomarkers and provide the evidence for the relationship between hyperuricemia and lipid-related diseases.
methodsLipidomics-a specialized study of lipid metabolites-has become a highly sensitive and powerful tool for biomarker discovery. In this work, an ultra-performance liquid chromatography-quadruole-time-of-flight tandem mass spectrometry (UPLC-Q-TOF/MS)-based on Lipidomics approach was employed to investigate serum samples from potassium oxonate-treated rats to find potential biomarkers. Principal component analysis (PCA) was used to analyze the MS data to assess the establishment of hyperuricemia model. Orthogonal partial least-squares discriminant analysis (OPLS-DA) in combination with independent samples t-test was performed for biomarker selection and identification.
resultsThirteen potential biomarkers in rat serum were identified in the screen, and two abnormal metabolism pathways were found, namely glycerolphospholipid metabolism and glycosylphosphatidylinositol-anchored protein biosynthesis.
conclusionsIn this work, the Lipidomics approach based on UPLC-Q-TOF/MS was employed to investigate serum metabolic changes in the rat model, 13 potential biomarkers related to hyperuricemia were identified, primarily involved in glycerolphospholipid metabolism and glycosylphosphatidylinositol-anchored protein biosynthesis. Abnormal glycerophospholipid metabolism pathway may be associated with lipid metabolism disorder caused by hyperuricemia, while the relationship between hyperuricemia and glycosylphosphatidylinositol-anchored protein biosynthesis needs further study.
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