ArticleWorld journal of surgical oncology2019
Associations between lymphovascular space invasion, nodal recurrence, and survival in patients with surgical stage I endometrioid endometrial adenocarcinoma.
Article in World journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluation of prognostic significance of lymphovascular space invasion in early stage endometrial cancer: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Prognostic significance of lymphovascular space invasion in endometrial cancer and its relationship with other prognostic factors.Journal of the Turkish German Gynecological Association · 2026Article
- Habitat model based on transvaginal ultrasound images for non-invasive prediction of lymphatic vessel interstitial infiltration in endometrial cancer.World journal of surgical oncology · 2026Article
- No survival benefit is associated with pelvic and para-aortic lymphadenectomy in lymph node-negative early-stage endometrioid endometrial cancer.BMC surgery · 2026Article
- Ultrasound based radiomics nomogram combined with clinical parameters to predict lymphovascular space invasion in endometrioid adenocarcinoma.Scientific reports · 2025Article
- Validation of 2023 FIGO Stage IA1-IIIC2 Endometrial Carcinoma: A Retrospective Analysis of Two Tertiary Centers in South Korea and Taiwan.Cancer research and treatment · 2025Article
- New FIGO 2023 Staging System of Endometrial Cancer: An Updated Review on a Current Hot Topic.Geburtshilfe und Frauenheilkunde · 2025Article
- Analysis of the Correlation between MRI Imaging Signs and Lymphovascular Space Invasion in Endometrial CancerCurrent medical imaging · 2025Article
- New clinicopathological concept of endometrial carcinoma with integration of histological features and molecular profiles.Pathology international · 2024Review
- Impact of adjuvant treatment on survival in patients with 2023 FIGO stage IIC endometrial cancer: a retrospective analysis from two tertiary centers in Korea and Taiwan.Journal of gynecologic oncology · 2024Article
- A novel predictive model of lymphovascular space invasion in early-stage endometrial cancer.Turkish journal of obstetrics and gynecology · 2024Article
- Predictors of recurrence and survival in lymphovascular space invasion negative early-stage endometrioid endometrial cancer patients.Journal of the Turkish German Gynecological Association · 2023Article
- Characterizing Lymphovascular Invasion in Pediatric and Adolescent Malignant Ovarian Nongerminomatous Germ Cell Tumors: A Report from the Children's Oncology Group.Journal of pediatric surgery · 2023Article
- FIGO staging of endometrial cancer: 2023.Journal of gynecologic oncology · 2023Article
- The impact of lymphovascular space invasion on survival in early stage low-grade endometrioid endometrial cancer.European journal of medical research · 2023Article
- Association of Lymphovascular Space Invasion (LVSI) with Histological Tumor Grade and Myometrial Invasion in Endometrial Carcinoma: A Review Study.Advanced biomedical research · 2023Review
- A predictive model based on site-specific risk factors of recurrence regions in endometrial cancer patients.BMC cancer · 2022Article
- Elevated AKIP1 expression is associated with tumor invasion, shorter survival time and decreased chemosensitivity in endometrial carcinoma.Oncology letters · 2022Article
- Observational
- Volumetric ADC histogram analysis for preoperative evaluation of LVSI status in stage I endometrioid adenocarcinoma.European radiology · 2022Article
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9 authors.
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Abstract
objectiveTo investigate the predictive value of lymphovascular space invasion (LVSI) for nodal recurrence and overall survival (OS) in patients with stage I endometrioid endometrial cancer (EC) following surgical staging that included adequate lymph node sampling.
methodsRetrospective analyses of patients undergoing surgical staging for FIGO stage I endometrioid EC between 1998 and 2015 were performed using an institutional database and the National Cancer Database (NCDB). Using the institutional database, logistic regression modeling identified predictors of nodal recurrence; Cox proportional hazards modeling was used to predict progression-free survival (PFS). Utilizing NCDB, Cox proportional hazards modeling was used to predict OS. The Kaplan-Meier method was used to estimate hazard ratios (HR). Survival curves were compared using the log-rank test.
resultsAmong 275 institutional cases, LVSI was present in 48 (17.5%). There were 11 nodal recurrences: 18.8% (9/48) of cases with LVSI had a nodal recurrence compared to 0.88% (2/227) of those without LVSI. In multivariate analysis of institutional data, LVSI was the only significant predictor of nodal recurrence (p = 0.002). Among 28,076 NCDB cases, LVSI was present in 3766 (13.5%). In multivariate analysis of NCDB, grade 3, LVSI, and depth of invasion (all p < 0.001) were prognostic for OS after adjusting for adjuvant radiation.
conclusionLVSI is an independent prognostic factor for nodal recurrence in stage I endometrial cancer with lymph node assessment. LVSI is associated with lower OS in NCDB. Given these findings, adjuvant therapy could be considered in these patients.
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