ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2020
Differences of the immune cell landscape between normal and tumor tissue in human prostate.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 28 citations in OpenAlex.
- Identification and validation of immune-related hub genes based on machine learning in prostate cancer and AOX1 is an oxidative stress-related biomarker.Frontiers in oncology · 2023Article
- Integrated Bioinformatic Analysis of DNA Methylation and Immune Infiltration in Endometrial Cancer.BioMed research international · 2022Article
- MFrontiers in genetics · 2022Article
- Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression.BMC cancer · 2021Article
- A New Ferroptosis-Related lncRNA Signature Predicts the Prognosis of Bladder Cancer Patients.Frontiers in cell and developmental biology · 2021Article
- Immune Cell Landscape in Gastric Cancer.BioMed research international · 2021Article
- The Association between Immune Infiltration and Clinical Phenotypes and Prognosis of Prostate Cancer.Iranian journal of biotechnology · 2020Article
- Identification of Immune Cell Landscape and Construction of a Novel Diagnostic Nomogram for Crohn's Disease.Frontiers in genetics · 2020Article
- The Landscape of Immune Cells Infiltrating in Prostate Cancer.Frontiers in oncology · 2020Article
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7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver the past few decades, immunological checkpoint therapy has been an increasingly prominent strategy in the treatment of tumors, including prostate cancer (PC). There are few systematic studies of the phenotypic of tumor-infiltrating immune cells in PC tissues.
methodsCIBERSORT is an analytical tool for estimating the abundance of member cell types in mixed cell population by gene expression data. Herein, we analyzed different levels of tumor-infiltrating immunity cells in normal tissue compared with PC using CIBERSORT.
resultsThe results showed that proportion of M1 macrophages and resting mast cells presented significant differences in prostate tumor than these normal tissues. A higher proportion of resting mast cells was associated with a worse outcome and M1 macrophages was associated with a favorable outcome. Moreover, the radiotherapy and targeted molecular therapy can affect the immune infiltration of M1 macrophages and resting mast cells.
conclusionsResting mast cells and M1 macrophages has an important role in the prognosis of prostate cancer. Our data provides valuable information about the future treatment of PC.
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