Evidence map›Paper›PMID 31077041›Full record

ArticleEnvironmental science and pollution research international2019

Distinctive fingerprints of genotoxicity induced by As, Cr, Cd, and Ni in a freshwater fish.

Meenu Singh, Huma Khan, Yeshvandra Verma, Suresh Vir Singh Rana

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Meenu SinghDepartment of Toxicology, Chaudhary Charan Singh University, Meerut, 250004, India.
Huma KhanDepartment of Toxicology, Chaudhary Charan Singh University, Meerut, 250004, India.
Yeshvandra VermaDepartment of Toxicology, Chaudhary Charan Singh University, Meerut, 250004, India.
Suresh Vir Singh RanaDepartment of Toxicology, Chaudhary Charan Singh University, Meerut, 250004, India. sureshvs_rana@yahoo.com.
Chaudhary Charan Singh University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genotoxicity of three toxic elements (chromium, cadmium, nickel) and a metalloid (arsenic) has been studied in a freshwater fish, Channa punctatus using micronuclei (MN) test, comet assay, and erythrocyte nuclear alterations (ENAs) as fingerprints of genotoxicity. These tests yielded different results suggesting involvement of different mechanisms for their genotoxicity. While highest frequency of blebbed nuclei was observed in chromium-treated fish (6.5 ± 0.76), lowest was observed in cadmium-treated fish (4.0 ± 1.0). Maximum number of notched nuclei was recorded in arsenic-treated fish (5.5 ± 1.15) whereas highest numbers of lobed nuclei were found in cadmium-treated fish (4.5 ± 0.13). These differences might be attributed to selective bioaccumulation and chemodynamics of each element. Other parameters used to determine genotoxicity viz.: lipid peroxidation and DNA damage also suggested different mechanisms of their genotoxicity. It is suggested that an integrative approach, using a battery of tests for determining genotoxicity, should be made while making environmental health risk assessment and ecotoxicological studies of these toxic elements.

Indexed as

DNA DamageAnimalsComet AssayErythrocytesFishesFresh WaterLipid PeroxidationMetals, HeavyMicronucleus TestsMutagensWater Pollutants, ChemicalMetals, HeavyMutagensWater Pollutants, ChemicalComet assayErythrocyte nuclear alterationsFishGenotoxicityMicronuclei test

Identifiers

PMID31077041
OpenAlexW2944043511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.