Evidence map›Paper›PMID 31076984›Full record

ArticleDigestive diseases and sciences2019

Does Biliodigestive Anastomosis Have Any Effect on the Reversal of Hepatopulmonary Syndrome in a Biliary Cirrhosis Experimental Model?

Leonardo Ervolino Corbi, Ana Cristina Aoun Tannuri, Maria Julia de Aro Braz, Vitor Ribeiro Paes, Lourenço Sbragia, Rebeca Lopes Figueira, Karina Miura da Costa, Maria Cecilia Mendonça Coelho, Josiane Oliveira Gonçalves, Suellen Serafini and 1 more

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Leonardo Ervolino CorbiPediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), University of Sao Paulo Medical School, São Paulo, Brazil.
Ana Cristina Aoun TannuriPediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), University of Sao Paulo Medical School, São Paulo, Brazil.
Maria Julia de Aro BrazPediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), University of Sao Paulo Medical School, São Paulo, Brazil.
Vitor Ribeiro PaesPediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), University of Sao Paulo Medical School, São Paulo, Brazil.
Lourenço SbragiaLaboratory of Experimental Fetal and Neonatal Surgery, Division of Pediatric Surgery - Department of Surgery and Anatomy, University of Sao Paulo Medical School, Ribeirão Prêto, Brazil.
Rebeca Lopes FigueiraLaboratory of Experimental Fetal and Neonatal Surgery, Division of Pediatric Surgery - Department of Surgery and Anatomy, University of Sao Paulo Medical School, Ribeirão Prêto, Brazil.
Karina Miura da CostaLaboratory of Experimental Fetal and Neonatal Surgery, Division of Pediatric Surgery - Department of Surgery and Anatomy, University of Sao Paulo Medical School, Ribeirão Prêto, Brazil.
Maria Cecilia Mendonça CoelhoPediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), University of Sao Paulo Medical School, São Paulo, Brazil.
Josiane Oliveira GonçalvesPediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), University of Sao Paulo Medical School, São Paulo, Brazil.
Suellen SerafiniPediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), University of Sao Paulo Medical School, São Paulo, Brazil.
Uenis TannuriPediatric Surgery Division, Pediatric Liver Transplantation Unit and Laboratory of Research in Pediatric Surgery (LIM 30), University of Sao Paulo Medical School, São Paulo, Brazil. uenist@usp.br.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiliary cirrhosis is associated with hepatopulmonary syndrome (HPS), which is related to increased posttransplant morbidity and mortality.

aimsThis study aims to analyze the pathophysiology of biliary cirrhosis and the onset of HPS.

methodsTwenty-one-day-old Wistar rats were subjected to common bile duct ligation and were allocated to two groups: group A (killed 2, 3, 4, 5, or 6 weeks after biliary obstruction) and group B (subjected to biliodigestive anastomosis 2, 3, 4, 5, or 6 weeks after the first procedure and killed 3 weeks later). At the killing, arterial blood was collected for the analyses, and samples from the liver and lungs were collected for histologic and molecular analyses. The gasometric parameters as well as the expression levels of ET-1, eNOS, and NOS genes in the lung tissue were evaluated.

resultsFrom a total of 42 blood samples, 15 showed hypoxemia (pO

conclusionsThe present model showed lung tissue alterations promoted by biliary obstruction. The biliodigestive anastomosis had no clear direct effects on these alterations.

Indexed as

Disease Models, AnimalAnastomosis, SurgicalAnimalsBile DuctsFemaleHepatopulmonary SyndromeLigationLiver Cirrhosis, BiliaryLungMaleRatsRats, WistarBile duct obstructionBiliary cirrhosisBiliary desobstructionCirrhosis reversibilityExperimental animal modelHepatopulmonary syndrome

Identifiers

PMID31076984
OpenAlexW2944770355

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.