ArticleEuropean radiology2019
Automated versus manual imaging assessment of early ischemic changes in acute stroke: comparison of two software packages and expert consensus.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- To Bridge or Not to Bridge? A Meta-Analysis of Intravenous Thrombolysis Before Thrombectomy in Large Ischemic Core Strokes.Brain and behavior · 2025Pooled it
- Effect of intravenous thrombolysis before endovascular therapy on outcomes in acute ischemic stroke with large core: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Software with artificial intelligence-derived algorithms for analysing CT brain scans in people with a suspected acute stroke: a systematic review and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2024Pooled it
- Clinical evaluation of an automated Alberta Stroke Program Early Computed Tomography Score (ASPECTS)-scoring system.Quantitative imaging in medicine and surgery · 2026Article
- Influence of deep learning image reconstruction and adaptive statistical iterative reconstruction-V on automated Alberta stroke program early CT score- evaluation.Neuroradiology · 2026Article
- Performance of an artificial intelligence tool for multi-step acute stroke imaging: A multicenter diagnostic study.European journal of radiology open · 2025Article
- Deep Learning-Based ASPECTS Algorithm Enhances Reader Performance and Reduces Interpretation Time.AJNR. American journal of neuroradiology · 2025Article
- Assessing the eligibility of Brainomix e-ASPECTS for acute stroke imaging.Frontiers in neuroinformatics · 2025Article
- Real-world evaluation of Brainomix e-Stroke software.Stroke and vascular neurology · 2024Article
- Localization of early infarction on non-contrast CT images in acute ischemic stroke with deep learning approach.Scientific reports · 2023Article
- Performance of Automated ASPECTS Software and Value as a Computer-Aided Detection Tool.AJNR. American journal of neuroradiology · 2023Article
- Machine learning and acute stroke imaging.Journal of neurointerventional surgery · 2023Review
- Impact of e-ASPECTS software on the performance of physicians compared to a consensus ground truth: a multi-reader, multi-case study.Frontiers in neurology · 2023Article
- Benefit and risk of intravenous alteplase in patients with acute large vessel occlusion stroke and low ASPECTS.Journal of neurointerventional surgery · 2023Article
- Validation of two automated ASPECTS software on non-contrast computed tomography scans of patients with acute ischemic stroke.Frontiers in neurology · 2023Article
- External Validation of e-ASPECTS Software for Interpreting Brain CT in Stroke.Annals of neurology · 2022Article
- Artificial Intelligence in Healthcare Competition (TEKNOFEST-2021): Stroke Data Set.The Eurasian journal of medicine · 2022Article
- e-ASPECTS software improves interobserver agreement and accuracy of interpretation of aspects score.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2021Article
- How to Improve the Management of Acute Ischemic Stroke by Modern Technologies, Artificial Intelligence, and New Treatment Methods.Life (Basel, Switzerland) · 2021Review
- Automated ASPECT scoring in acute ischemic stroke: comparison of three software tools.Neuroradiology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe purpose of our study was to compare the agreement of both the total Alberta Stroke Program Early CT Score (ASPECTS) and region-based scores from two automated ASPECTS software packages and an expert consensus (EC) reading with final ASPECTS in a selected cohort of patients who had prompt reperfusion from endovascular thrombectomy (EVT).
methodsASPECTS were retrospectively and blindly assessed by two software packages and EC on baseline non-contrast-enhanced computed tomography (NCCT) images. All patients had multimodal CT imaging including NCCT, CT angiography, and CT perfusion which demonstrated an acute anterior circulation ischemic stroke with a large vessel occlusion. Final ASPECTS on follow-up scans in patients who had EVT and achieved complete reperfusion within 100 min from NCCT served as ground truth and were compared to total and region-based scores.
resultsFifty-two patients met our study criteria. Moderate agreement was obtained between both software packages and EC for total ASPECTS and there was no significant difference in overall performance. However, the software packages differed with respect to regional contribution. In this cohort, the majority of infarcted regions were deep structures. Package A was more sensitive in cortical areas than the other methods, but at a cost of specificity. EC and software package B had greater sensitivity, but lower specificity for deep brain structures.
conclusionIn this cohort, using the final ASPECTS as ground truth, no clinically significant difference was observed for total ASPECT score between human or automated packages, but there were differences in the characteristics of the regions scored. KEY POINTS: • Some national stroke guidelines have incorporated ASPECTS in their recommendations for selecting patients for endovascular therapy. • Computer-aided diagnosis is a promising tool to aid the evaluation of early ischemic changes identified on CT. • Software packages for automated ASPECTS assessment differed significantly with respect to regional contribution without any significant difference in the overall ASPECT score.
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