Trial reportEuropean journal of nutrition2020
B-vitamins and body composition: integrating observational and experimental evidence from the B-PROOF study.
Trial report in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Novel Anthropometric Indices and Probability of Adequate Nutrient Intake in the Older Polish Population.Nutrients · 2025Article
- The correlation between different lifestyles and body composition focuses on eating habits, nutritional status, and physical exercise components.Hormones (Athens, Greece) · 2025Review
- Age-specific associations of RBC folate and several serum folate forms with obesity risk: NHANES 2011-2018.Frontiers in nutrition · 2025Article
- The intake of ultra-processed foods and homocysteine levels in women with(out) overweight and obesity: The Rotterdam Periconceptional Cohort.European journal of nutrition · 2024Article
- The visceral adipose tissue bacterial microbiota provides a signature of obesity based on inferred metagenomic functions.International journal of obesity (2005) · 2023Article
- Association of the DNA Methylation of Obesity-Related Genes with the Dietary Nutrient Intake in Children.Nutrients · 2023Article
- Suppression of high-fat-diet-induced obesity in mice by dietary folic acid supplementation is linked to changes in gut microbiota.European journal of nutrition · 2022Article
- Causal effects of B vitamins and homocysteine on obesity and musculoskeletal diseases: A Mendelian randomization study.Frontiers in nutrition · 2022Article
- Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study.Nutrition journal · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
purposeHigher folate and vitamin-B12 have been linked to lower risk of overweight. However, whether this is a causal effect of these B-vitamins on obesity risk remains unclear and evidence in older individuals is scarce. This study aimed to assess the role of B-vitamin supplementation and levels on body composition in older individuals.
methodsA double-blind, randomized controlled trial in 2919 participants aged ≥ 65 years with elevated homocysteine levels. The intervention comprised a 2-year supplementation with a combination of folic acid (400 µg) and vitamin B12 (500 µg), or with placebo. Serum folate, vitamin-B12, active vitamin-B12 (HoloTC), methylmalonic acid (MMA), and anthropometrics were measured at baseline and after 2 years of follow-up. Dietary intake of folate and vitamin-B12 was measured at baseline in a subsample (n = 603) using a validated food-frequency questionnaire. Fat mass index (FMI) and fat-free mass index (FFMI) were assessed with Dual Energy X-ray absorptiometry (DXA).
resultsCross-sectional analyses showed that a 1 nmol/L higher serum folate was associated with a 0.021 kg/m
conclusionsAlthough observational data suggested that folate and vitamin B12 status are associated with body composition, random allocation of a supplement with both B-vitamins combined versus placebo did not confirm an effect on BMI or body composition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.