ArticleGenome biology and evolution2019
Revisiting the Evolution and Taxonomy of Clostridia, a Phylogenomic Update.
Article in Genome biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Article
- Comparative pangenomics unveils distinct host adaptation trends and conserved biosynthetic potential in microbiome Clostridia.Molecular biology and evolution · 2026Article
- Integrating Metabolic Modeling and Targeted Supplementation for the Rapid Detection ofMicroorganisms · 2026Article
- Reliable delineation ofMicrobiology spectrum · 2026Article
- Anaerobic digestate fertilization reshapes the rhizosphere bacterial communities of Lolium perenne L. at compositional and predicted functional potential levels.World journal of microbiology & biotechnology · 2026Article
- Article
- Clostridium zhoujianii sp. nov., a novel gram-negative species isolated from bat feces and its genetic characteristics.BMC microbiology · 2026Article
- Genomic insights into the functional and metabolic versatility of gut microbiomeMicrobial genomics · 2026Article
- Relationship of electrochemical performance and biofilm development ofFrontiers in microbiology · 2026Article
- Fate ofFrontiers in microbiology · 2026Article
- AnMicroorganisms · 2025Article
- Genetic diversity and evolutionary adaptation of Clostridium paraputrificum, a rare pathogen in humans.Communications biology · 2025Article
- Challenges and Opportunities in Analyzing Cancer-Associated Microbiomes.Cancer research · 2025Review
- Article
- Development of microfluidic ELISA for measuring humoral responses to clostridial antigens in vaccinated cattle.Journal of immunological methods · 2025Article
- Characterisation of the Faecal Microbiota in Dogs with Mast Cell Tumours Compared with Healthy Dogs.Animals : an open access journal from MDPI · 2025Article
- 'What's in a name? Fit-for-purpose bacterial nomenclature': meeting report.International journal of systematic and evolutionary microbiology · 2025Review
- Metagenomics-based tracing of genetically modified microorganism contaminations in commercial fermentation products.Food chemistry. Molecular sciences · 2025Article
- Species evolution: cryptic species and phenotypic noise with a particular focus on fungal systematics.Frontiers in cellular and infection microbiology · 2025Review
- Effects of feeding mycotoxin-contaminated diets and the use of a yeast cell wall extracts mycotoxin adsorbent on ruminal and fecal microbiota of finishing beef steers.Frontiers in microbiology · 2025Article
11 more citing papers are in PubMed but not listed here.
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Clostridium is a large genus of obligate anaerobes belonging to the Firmicutes phylum of bacteria, most of which have a Gram-positive cell wall structure. The genus includes significant human and animal pathogens, causative of potentially deadly diseases such as tetanus and botulism. Despite their relevance and many studies suggesting that they are not a monophyletic group, the taxonomy of the group has largely been neglected. Currently, species belonging to the genus are placed in the unnatural order defined as Clostridiales, which includes the class Clostridia. Here, we used genomic data from 779 strains to study the taxonomy and evolution of the group. This analysis allowed us to 1) confirm that the group is composed of more than one genus, 2) detect major differences between pathogens classified as a single species within the group of authentic Clostridium spp. (sensu stricto), 3) identify inconsistencies between taxonomy and toxin evolution that reflect on the pervasive misclassification of strains, and 4) identify differential traits within central metabolism of members of what has been defined earlier and confirmed by us as cluster I. Our analysis shows that the current taxonomic classification of Clostridium species hinders the prediction of functions and traits, suggests a new classification for this fascinating class of bacteria, and highlights the importance of phylogenomics for taxonomic studies.
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