Evidence map›Paper›PMID 31076640›Full record

ArticleScientific reports2019

Attenuated NoGo-related beta desynchronisation and synchronisation in Parkinson's disease revealed by magnetoencephalographic recording.

Hung-Ming Wu, Fu-Jung Hsiao, Rou-Shayn Chen, Din-E Shan, Wan-Yu Hsu, Ming-Chang Chiang, Yung-Yang Lin

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hung-Ming WuInstitute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Fu-Jung HsiaoInstitute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Rou-Shayn ChenDepartment of Neurology, LinKou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Din-E ShanDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Wan-Yu HsuInstitute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Ming-Chang ChiangDepartment of Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan.
Yung-Yang LinInstitute of Brain Science, National Yang-Ming University, Taipei, Taiwan. yylin@vghtpe.gov.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterised by motor abnormalities. Many non-demented patients with PD have cognitive impairment especially in executive functions. Using magnetoencephalographic (MEG) recording combined with event-related desynchronisation/synchronisation (ERD/ERS) analysis, we investigated cortical executive functions during a Go/NoGo task in PD patients and matched healthy subjects. PD patients had a longer reaction time in the Go condition and had a higher error ratio in both Go and NoGo conditions. The MEG analysis showed that the PD patients had a significant reduction in beta ERD during the NoGo condition and in beta ERS during both Go and NoGo conditions compared with the healthy subjects (all p < 0.05). Moreover, in the Go condition, the onsets of beta ERD and ERS were delayed in PD patients. Notably, NoGo ERS was negatively correlated with the Unified Parkinson's Disease Rating Scale (UPDRS) score in PD patients. The present study demonstrated abnormalities in motor programming, response inhibition, and frontal inhibitory modulation in PD. Further extensive investigations are necessary to confirm the longitudinal treatment responses in PD.

Indexed as

AgedCognitionCognitive DysfunctionCortical SynchronizationExecutive FunctionFemaleHumansMagnetoencephalographyMaleMiddle AgedParkinson DiseaseReaction Time

Identifiers

PMID31076640
PMCPMC6510752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.