Evidence map›Paper›PMID 31076590›Full record

ArticleScientific reports2019

Hemidesmus indicus induces apoptosis via proteasome inhibition and generation of reactive oxygen species.

Eleonora Turrini, Elena Catanzaro, Lorenzo Ferruzzi, Alessandra Guerrini, Massimo Tacchini, Gianni Sacchetti, Guglielmo Paganetto, Francesca Maffei, Valentina Pellicioni, Ferruccio Poli and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Overview of the Anticancer Profile of Avenanthramides from Oat.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eleonora TurriniDepartment for Life Quality Studies, University of Bologna, Rimini, Italy.ORCID http://orcid.org/0000-0003-4743-1126
Elena CatanzaroDepartment for Life Quality Studies, University of Bologna, Rimini, Italy.
Lorenzo FerruzziDepartment for Life Quality Studies, University of Bologna, Rimini, Italy.
Alessandra GuerriniDepartment of Life Sciences and Biotechnology, University of Ferrara, Malborghetto di Boara, Ferrara, Italy.
Massimo TacchiniDepartment of Life Sciences and Biotechnology, University of Ferrara, Malborghetto di Boara, Ferrara, Italy.
Gianni SacchettiDepartment of Life Sciences and Biotechnology, University of Ferrara, Malborghetto di Boara, Ferrara, Italy.
Guglielmo PaganettoDepartment of Life Sciences and Biotechnology, University of Ferrara, Malborghetto di Boara, Ferrara, Italy.
Francesca MaffeiDepartment for Life Quality Studies, University of Bologna, Rimini, Italy.
Valentina PellicioniDepartment for Life Quality Studies, University of Bologna, Rimini, Italy.
Ferruccio PoliDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Patrizia HreliaDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Manuela MandroneDepartment of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Piero SestiliDepartment of Biomolecular Sciences, University of Urbino "Carlo Bo", Urbino, Italy.
Maurizio BrigottiDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.ORCID http://orcid.org/0000-0001-7429-744X
Carmela FimognariDepartment for Life Quality Studies, University of Bologna, Rimini, Italy. carmela.fimognari@unibo.it.ORCID http://orcid.org/0000-0002-2461-8214

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteasome inhibition represents an important anticancer strategy. Here, we studied the mechanisms at the basis of the pro-apoptotic activity of the standardized decoction of Hemidesmus indicus, a plant evoking a complex anticancer activity, and explored its inhibition of proteasome activity in human leukemia cells. Additionally, we preliminary tested the cytotoxicity of some H. indicus's phytochemicals on leukemia cells and their intestinal absorption on a human intestinal epithelium model consisting of a monolayer of differentiated Caco2 cells. We observed a potent antileukemic effect for H. indicus, imputable to the modulation of different critical targets at protein and mRNA levels and the reduction of the 26S proteasome expression. We found that some phytomarkers of H. indicus decoction passed through the enterocyte monolayer. Overall, our study supports the pharmacological potential of H. indicus, which can represent an interesting botanical drug in the oncological area.

Indexed as

Antineoplastic Agents, PhytogenicCaco-2 CellsCell DifferentiationCell ProliferationCell SurvivalGene Expression Regulation, NeoplasticHemidesmusHumansIntestinal AbsorptionJurkat CellsMicroRNAsPlant ExtractsPlant RootsProteasome Endopeptidase ComplexProteasome InhibitorsReactive Oxygen SpeciesAntineoplastic Agents, PhytogenicATP dependent 26S proteaseMicroRNAsMIRN15 microRNA, humanMIRN16 microRNA, humanPlant ExtractsProteasome Endopeptidase ComplexProteasome InhibitorsReactive Oxygen Species

Identifiers

PMID31076590
PMCPMC6510901

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.