ArticleProceedings of the National Academy of Sciences of the United States of America2019
High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Mechanophore-Based Multichannel Colorimetric Force Sensors: Ultrasound-Driven Stress and Strain Quantification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- In vivo ultrasound-induced luminescence imaging via trianthracene derivatives nanomaterials.Nature protocols · 2026Review
- Ultrasound-induced luminescence imaging for deep tissues.Theranostics · 2026Review
- Piezoelectric electrospun scaffold incorporating ibuprofen loaded ultrasound-responsive mesoporous silica nanoparticles for tissue regeneration.RSC advances · 2025Article
- Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy.ACS applied bio materials · 2024Review
- Multimechanophore Polymers for Mechanically Triggered Small Molecule Release with Ultrahigh Payload Capacity.Journal of the American Chemical Society · 2024Article
- Light on Alzheimer's disease: from basic insights to preclinical studies.Frontiers in aging neuroscience · 2024Review
- Ultrasound-Induced Cascade Amplification in a Mechanoluminescent Nanotransducer for Enhanced Sono-Optogenetic Deep Brain Stimulation.ACS nano · 2023Article
- Naphthopyran molecular switches and their emergent mechanochemical reactivity.Chemical science · 2023Review
- Remote control of mechanochemical reactions under physiological conditions using biocompatible focused ultrasound.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mechanically gated formation of donor-acceptor Stenhouse adducts enabling mechanochemical multicolour soft lithography.Nature chemistry · 2023Article
- Ultrasound-Triggered In Situ Photon Emission for Noninvasive Optogenetics.Journal of the American Chemical Society · 2023Article
- Mechanoluminescent Materials Enable Mechanochemically Controlled Atom Transfer Radical Polymerization and Polymer Mechanotransduction.Research (Washington, D.C.) · 2023Article
- Force ahead: Emerging Applications and Opportunities of Polymer Mechanochemistry.ACS polymers Au · 2022Article
- Ultrasound triggered organic mechanoluminescence materials.Advanced drug delivery reviews · 2022Review
- Noninvasive and Spatiotemporal Control of DNAzyme-Based Imaging of Metal IonsJournal of the American Chemical Society · 2022Article
- Perfluorooctyl bromide nanoemulsions holding MnOActa pharmaceutica Sinica. B · 2022Article
- Ultrasound controlled mechanophore activation in hydrogels for cancer therapy.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Ultrasound-controlled drug release and drug activation for cancer therapy.Exploration (Beijing, China) · 2021Review
- A modular approach to mechanically gated photoswitching with color-tunable molecular force probes.Chemical science · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
While study in the field of polymer mechanochemistry has yielded mechanophores that perform various chemical reactions in response to mechanical stimuli, there is not yet a triggering method compatible with biological systems. Applications such as using mechanoluminescence to generate localized photon flux in vivo for optogenetics would greatly benefit from such an approach. Here we introduce a method of triggering mechanophores by using high-intensity focused ultrasound (HIFU) as a remote energy source to drive the spatially and temporally resolved mechanical-to-chemical transduction of mechanoresponsive polymers. A HIFU setup capable of controlling the excitation pressure, spatial location, and duration of exposure is employed to activate mechanochemical reactions in a cross-linked elastomeric polymer in a noninvasive fashion. One reaction is the chromogenic isomerization of a naphthopyran mechanophore embedded in a polydimethylsiloxane (PDMS) network. Under HIFU irradiation evidence of the mechanochemical transduction is the observation of a reversible color change as expected for the isomerization. The elastomer exhibits this distinguishable color change at the focal spot, depending on ultrasonic exposure conditions. A second reaction is the demonstration that HIFU irradiation successfully triggers a luminescent dioxetane, resulting in localized generation of visible blue light at the focal spot. In contrast to conventional stimuli such as UV light, heat, and uniaxial compression/tension testing, HIFU irradiation provides spatiotemporal control of the mechanochemical activation through targeted but noninvasive ultrasonic energy deposition. Targeted, remote light generation is potentially useful in biomedical applications such as optogenetics where a light source is used to trigger a cellular response.
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